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- W2034790724 abstract "For the past 25 years, efforts have been made to stop progression of type 1 diabetes by immunotherapeutic strategies targeting autoimmune mechanism(s) involved in the disease. In the mid-1980s, chemical immunosuppression with ciclosporin proved a successful intervention in advanced disease, once hyperglycaemia had been established. 1 Feutren G Papoz L Assan R et al. Cyclosporin increases the rate and length of remissions in insulin-dependent diabetes of recent onset. Results of a multicentre double-blind trial. Lancet. 1986; 328: 119-124 Summary Scopus (356) Google Scholar As expected, however, the effect persisted only during drug administration, which implied a requirement for chronic treatment that would be incompatible with the prerequisites of safety in type 1 diabetes—a disease that preferentially affects children and young adults. Teplizumab for treatment of type 1 diabetes (Protégé study): 1-year results from a randomised, placebo-controlled trialFindings of exploratory analyses suggest that future studies of immunotherapeutic intervention with teplizumab might have increased success in prevention of a decline in β-cell function (measured by C-peptide) and provision of glycaemic control at reduced doses of insulin if they target patients early after diagnosis of diabetes and children. Full-Text PDF" @default.
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- W2034790724 date "2011-08-01" @default.
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- W2034790724 title "Anti-CD3 antibodies for type 1 diabetes: beyond expectations" @default.
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- W2034790724 doi "https://doi.org/10.1016/s0140-6736(11)60980-x" @default.
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