FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034790817> ?p ?o ?g. }

• W2034790817 endingPage "908" @default.
• W2034790817 startingPage "903" @default.
• W2034790817 abstract "The small guanosine triphosphatase RhoA/Rho-kinase cascade has been implicated in uterine contraction. Our purpose was to evaluate the tocolytic effect of a Rho-kinase inhibitor, Y-27632, in lipopolysaccharide-induced preterm delivery in mice.We used an animal model of lipopolysaccharide-induced preterm delivery in C3H/HeN x B6D2F1 pregnant mice. Y-27632 was delivered continuously through an osmotic pump that was implanted into the peritoneal cavity 6 hours before lipopolysaccharide treatment. The primary outcome was the preterm delivery rate. To further study the possible involvement of this cascade in lipopolysaccharide-induced preterm delivery, we determined the effect of lipopolysaccharide and prostaglandin F2alpha on RhoA activation in mouse myometrial cells and uterine smooth muscle tissues.The rate of preterm delivery for lipopolysaccharide-treated animals was 94.4%. The administration of Y-27632 (1 or 10 mg/kg/d) significantly reduced the preterm delivery rate to 61.1% or 15.8%, respectively. The level of guanosine triphosphate-bound RhoA was increased after the addition of lipopolysaccharide or prostaglandin F2alpha.The RhoA/Rho-kinase cascade is involved in lipopolysaccharide-induced preterm delivery, which suggests that Rho-kinase could be used as a new therapeutic target for the prevention of preterm labor." @default.
• W2034790817 created "2016-06-24" @default.
• W2034790817 creator A5001425851 @default.
• W2034790817 creator A5006897018 @default.
• W2034790817 creator A5019463160 @default.
• W2034790817 creator A5034831994 @default.
• W2034790817 creator A5040789531 @default.
• W2034790817 creator A5046721669 @default.
• W2034790817 creator A5077323530 @default.
• W2034790817 date "2005-03-01" @default.
• W2034790817 modified "2023-10-16" @default.
• W2034790817 title "Tocolytic effect of a Rho-kinase inhibitor in a mouse model of lipopolysaccharide-induced preterm delivery" @default.
• W2034790817 cites W1514066364 @default.
• W2034790817 cites W1925229827 @default.
• W2034790817 cites W1968330391 @default.
• W2034790817 cites W1971262237 @default.
• W2034790817 cites W1986240321 @default.
• W2034790817 cites W1990940102 @default.
• W2034790817 cites W2016224110 @default.
• W2034790817 cites W2016504297 @default.
• W2034790817 cites W2028822365 @default.
• W2034790817 cites W2029042181 @default.
• W2034790817 cites W2037067429 @default.
• W2034790817 cites W2047482446 @default.
• W2034790817 cites W2077792958 @default.
• W2034790817 cites W2080600489 @default.
• W2034790817 cites W2085781070 @default.
• W2034790817 cites W2088483796 @default.
• W2034790817 cites W2089742414 @default.
• W2034790817 cites W2093782142 @default.
• W2034790817 cites W2093953702 @default.
• W2034790817 cites W2125312335 @default.
• W2034790817 cites W2142221896 @default.
• W2034790817 cites W2142688270 @default.
• W2034790817 cites W2165969546 @default.
• W2034790817 cites W2247361254 @default.
• W2034790817 cites W2313220264 @default.
• W2034790817 cites W2404755821 @default.
• W2034790817 doi "https://doi.org/10.1016/j.ajog.2004.09.016" @default.
• W2034790817 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15746689" @default.
• W2034790817 hasPublicationYear "2005" @default.
• W2034790817 type Work @default.
• W2034790817 sameAs 2034790817 @default.
• W2034790817 citedByCount "19" @default.
• W2034790817 countsByYear W20347908172012 @default.
• W2034790817 countsByYear W20347908172013 @default.
• W2034790817 countsByYear W20347908172014 @default.
• W2034790817 countsByYear W20347908172016 @default.
• W2034790817 countsByYear W20347908172018 @default.
• W2034790817 countsByYear W20347908172019 @default.
• W2034790817 countsByYear W20347908172021 @default.
• W2034790817 countsByYear W20347908172023 @default.
• W2034790817 crossrefType "journal-article" @default.
• W2034790817 hasAuthorship W2034790817A5001425851 @default.
• W2034790817 hasAuthorship W2034790817A5006897018 @default.
• W2034790817 hasAuthorship W2034790817A5019463160 @default.
• W2034790817 hasAuthorship W2034790817A5034831994 @default.
• W2034790817 hasAuthorship W2034790817A5040789531 @default.
• W2034790817 hasAuthorship W2034790817A5046721669 @default.
• W2034790817 hasAuthorship W2034790817A5077323530 @default.
• W2034790817 hasConcept C126322002 @default.
• W2034790817 hasConcept C134018914 @default.
• W2034790817 hasConcept C16685009 @default.
• W2034790817 hasConcept C184235292 @default.
• W2034790817 hasConcept C185592680 @default.
• W2034790817 hasConcept C201800478 @default.
• W2034790817 hasConcept C2777093181 @default.
• W2034790817 hasConcept C2778609687 @default.
• W2034790817 hasConcept C2778754761 @default.
• W2034790817 hasConcept C2779234561 @default.
• W2034790817 hasConcept C2780664492 @default.
• W2034790817 hasConcept C2780994212 @default.
• W2034790817 hasConcept C2908881489 @default.
• W2034790817 hasConcept C3019152611 @default.
• W2034790817 hasConcept C46973012 @default.
• W2034790817 hasConcept C519581460 @default.
• W2034790817 hasConcept C54355233 @default.
• W2034790817 hasConcept C55493867 @default.
• W2034790817 hasConcept C62478195 @default.
• W2034790817 hasConcept C71924100 @default.
• W2034790817 hasConcept C86803240 @default.
• W2034790817 hasConcept C98274493 @default.
• W2034790817 hasConceptScore W2034790817C126322002 @default.
• W2034790817 hasConceptScore W2034790817C134018914 @default.
• W2034790817 hasConceptScore W2034790817C16685009 @default.
• W2034790817 hasConceptScore W2034790817C184235292 @default.
• W2034790817 hasConceptScore W2034790817C185592680 @default.
• W2034790817 hasConceptScore W2034790817C201800478 @default.
• W2034790817 hasConceptScore W2034790817C2777093181 @default.
• W2034790817 hasConceptScore W2034790817C2778609687 @default.
• W2034790817 hasConceptScore W2034790817C2778754761 @default.
• W2034790817 hasConceptScore W2034790817C2779234561 @default.
• W2034790817 hasConceptScore W2034790817C2780664492 @default.
• W2034790817 hasConceptScore W2034790817C2780994212 @default.
• W2034790817 hasConceptScore W2034790817C2908881489 @default.
• W2034790817 hasConceptScore W2034790817C3019152611 @default.
• W2034790817 hasConceptScore W2034790817C46973012 @default.
• W2034790817 hasConceptScore W2034790817C519581460 @default.

• next