FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034794811> ?p ?o ?g. }

• W2034794811 endingPage "366" @default.
• W2034794811 startingPage "348" @default.
• W2034794811 abstract "Members of the UNC-5 protein family are transmembrane receptors for UNC-6/netrin guidance cues. To analyze the functional roles of different UNC-5 domains, we sequenced mutations in seven severe and three weak alleles of unc-5 in Caenorhabditis elegans. Four severe alleles contain nonsense mutations. Two weak alleles are truncations of the cytodomain, but one is a missense mutation in an extracellular immunoglobulin domain. To survey the function of different regions of UNC-5, wild-type and mutant unc-5::HA transgenes were tested for their ability to rescue the unc-5(e53) null mutant. Our data reveal partial functional requirements for the extracellular domains and identify a portion of the cytoplasmic juxtamembrane (JM) region as essential for rescue of migrations. When nine cytodomain tyrosines, including seven in the JM region, are mutated to phenylalanine, UNC-5 function and tyrosine phosphorylation are largely compromised. When F482 in the JM region of the mutant protein is reverted to tyrosine, UNC-5 tyrosine phosphorylation and in vivo function are largely recovered, suggesting that Y482 phosphorylation is critical to UNC-5 function in vivo. Our data also show that part of the ZU-5 motif is required for UNC-40-independent signaling of UNC-5." @default.
• W2034794811 created "2016-06-24" @default.
• W2034794811 creator A5019065056 @default.
• W2034794811 creator A5019176068 @default.
• W2034794811 creator A5028529181 @default.
• W2034794811 creator A5064735255 @default.
• W2034794811 creator A5077093856 @default.
• W2034794811 creator A5078917243 @default.
• W2034794811 creator A5090328187 @default.
• W2034794811 date "2002-11-01" @default.
• W2034794811 modified "2023-10-14" @default.
• W2034794811 title "UNC-5 Function Requires Phosphorylation of Cytoplasmic Tyrosine 482, but Its UNC-40-Independent Functions also Require a Region between the ZU-5 and Death Domains" @default.
• W2034794811 cites W1531884080 @default.
• W2034794811 cites W1559752086 @default.
• W2034794811 cites W1581412826 @default.
• W2034794811 cites W1933058796 @default.
• W2034794811 cites W1944127002 @default.
• W2034794811 cites W1964817578 @default.
• W2034794811 cites W1966272997 @default.
• W2034794811 cites W1967450020 @default.
• W2034794811 cites W1976179891 @default.
• W2034794811 cites W1976293694 @default.
• W2034794811 cites W1977922844 @default.
• W2034794811 cites W1981758063 @default.
• W2034794811 cites W1982719475 @default.
• W2034794811 cites W1984470518 @default.
• W2034794811 cites W1988196067 @default.
• W2034794811 cites W1991591664 @default.
• W2034794811 cites W1996027687 @default.
• W2034794811 cites W1998312044 @default.
• W2034794811 cites W1998541740 @default.
• W2034794811 cites W2006108102 @default.
• W2034794811 cites W2012109762 @default.
• W2034794811 cites W2017257935 @default.
• W2034794811 cites W2018396790 @default.
• W2034794811 cites W2024732305 @default.
• W2034794811 cites W2025062892 @default.
• W2034794811 cites W2031209863 @default.
• W2034794811 cites W2032473517 @default.
• W2034794811 cites W2032579724 @default.
• W2034794811 cites W2036473961 @default.
• W2034794811 cites W2036662864 @default.
• W2034794811 cites W2037525283 @default.
• W2034794811 cites W2042643679 @default.
• W2034794811 cites W2043124311 @default.
• W2034794811 cites W2045172642 @default.
• W2034794811 cites W2046968637 @default.
• W2034794811 cites W2047166961 @default.
• W2034794811 cites W2048607748 @default.
• W2034794811 cites W2050430335 @default.
• W2034794811 cites W2051440844 @default.
• W2034794811 cites W2055613750 @default.
• W2034794811 cites W2056862346 @default.
• W2034794811 cites W2060015752 @default.
• W2034794811 cites W2061172411 @default.
• W2034794811 cites W2067078431 @default.
• W2034794811 cites W2069531056 @default.
• W2034794811 cites W2069873661 @default.
• W2034794811 cites W2073231646 @default.
• W2034794811 cites W2075086498 @default.
• W2034794811 cites W2076202639 @default.
• W2034794811 cites W2079128745 @default.
• W2034794811 cites W2079449212 @default.
• W2034794811 cites W2086349309 @default.
• W2034794811 cites W2089405081 @default.
• W2034794811 cites W2090865074 @default.
• W2034794811 cites W2096439960 @default.
• W2034794811 cites W2101671662 @default.
• W2034794811 cites W2117713674 @default.
• W2034794811 cites W2123361468 @default.
• W2034794811 cites W2124248841 @default.
• W2034794811 cites W2133550787 @default.
• W2034794811 cites W2133960052 @default.
• W2034794811 cites W2146200404 @default.
• W2034794811 cites W2154616416 @default.
• W2034794811 cites W2168344733 @default.
• W2034794811 cites W2171288353 @default.
• W2034794811 cites W2185351394 @default.
• W2034794811 cites W2463471618 @default.
• W2034794811 cites W4213380953 @default.
• W2034794811 cites W4230920387 @default.
• W2034794811 cites W4255093289 @default.
• W2034794811 doi "https://doi.org/10.1006/dbio.2002.0825" @default.
• W2034794811 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12435363" @default.
• W2034794811 hasPublicationYear "2002" @default.
• W2034794811 type Work @default.
• W2034794811 sameAs 2034794811 @default.
• W2034794811 citedByCount "69" @default.
• W2034794811 countsByYear W20347948112012 @default.
• W2034794811 countsByYear W20347948112013 @default.
• W2034794811 countsByYear W20347948112014 @default.
• W2034794811 countsByYear W20347948112015 @default.
• W2034794811 countsByYear W20347948112016 @default.
• W2034794811 countsByYear W20347948112017 @default.
• W2034794811 countsByYear W20347948112018 @default.
• W2034794811 countsByYear W20347948112019 @default.
• W2034794811 countsByYear W20347948112021 @default.
• W2034794811 countsByYear W20347948112022 @default.

• next