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- W2034796827 abstract "The authors present a case of Philadelphia (Ph1) positive acute myeloblastic leukemia (AML) following a refractory anemia with excess of blasts (RAEB) that had been Ph1-negative for 17 months. During the transformation of RAEB into AML, the Ph1 was discovered in 100% of the examined cells. With therapy a partial remission was obtained, during which some 46,XY cells reappeared mixed with Ph1 cells along with a new clone: 47,XY,+11 originating from a Ph1-negative cell. During the terminal blast crisis, the karyotype returned to 46,XY,Ph1. The AML lasted 21 months. The authors discuss: (1) the significance of Ph1-positive AML with a review of the literature; (2) the de novo acquisition of a Ph1 during the course of a blood disorder; and (3) the meaning of a second abnormal clone originating from 46,XY cells." @default.
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- W2034796827 date "1985-04-01" @default.
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- W2034796827 title "Acquisition of a Philadelphia chromosome concomitant with transformation of a refractory anemia into an acute leukemia" @default.
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- W2034796827 doi "https://doi.org/10.1002/1097-0142(19850401)55:7<1477::aid-cncr2820550710>3.0.co;2-a" @default.
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