Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034797416> ?p ?o ?g. }
- W2034797416 endingPage "1519" @default.
- W2034797416 startingPage "1515" @default.
- W2034797416 abstract "Whole human saliva contains a number of proteolytic enzymes, mostly derived from white blood cells and bacteria in the oral cavity. However, less information is available regarding proteases produced by salivary glands and present in salivary secretions. In the present study, we have analyzed submandibular saliva, collected without contaminating cells, and identified multiple proteolytic activities. These have been characterized in terms of their susceptibility to a series of protease inhibitors. The submandibular saliva proteases were shown to be sensitive to both serine and acidic protease inhibitors. We also used protease inhibitors to determine if salivary proteolytic activity was involved in the inhibition of HIV infectivity seen when the virus is incubated with human saliva. This anti-HIV activity has been reported to occur in whole saliva and in ductal saliva obtained from both the parotid and submandibular glands, with highest levels of activity present in the latter fluid. Protease inhibitors, at concentrations sufficient to block salivary proteolytic activity in an in vitro infectivity assay, did not block the anti-HIV effects of saliva, suggesting that the salivary proteases are not responsible for the inhibition of HIV-1 infectivity." @default.
- W2034797416 created "2016-06-24" @default.
- W2034797416 creator A5013738913 @default.
- W2034797416 creator A5022736570 @default.
- W2034797416 creator A5029734068 @default.
- W2034797416 creator A5046248935 @default.
- W2034797416 creator A5057072991 @default.
- W2034797416 creator A5073382503 @default.
- W2034797416 creator A5027806063 @default.
- W2034797416 date "1998-07-01" @default.
- W2034797416 modified "2023-09-28" @default.
- W2034797416 title "Submandibular Salivary Proteases: Lack of a Role in Anti-HIV Activity" @default.
- W2034797416 cites W1480555318 @default.
- W2034797416 cites W1905476146 @default.
- W2034797416 cites W1935830129 @default.
- W2034797416 cites W1968009123 @default.
- W2034797416 cites W1997897809 @default.
- W2034797416 cites W1999141010 @default.
- W2034797416 cites W2004363016 @default.
- W2034797416 cites W2005034997 @default.
- W2034797416 cites W2008972159 @default.
- W2034797416 cites W2017510278 @default.
- W2034797416 cites W2030828063 @default.
- W2034797416 cites W2054684353 @default.
- W2034797416 cites W2056059709 @default.
- W2034797416 cites W2070236534 @default.
- W2034797416 cites W2081935689 @default.
- W2034797416 cites W2136088948 @default.
- W2034797416 cites W4237410627 @default.
- W2034797416 cites W4777192 @default.
- W2034797416 doi "https://doi.org/10.1177/00220345980770070601" @default.
- W2034797416 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9663436" @default.
- W2034797416 hasPublicationYear "1998" @default.
- W2034797416 type Work @default.
- W2034797416 sameAs 2034797416 @default.
- W2034797416 citedByCount "19" @default.
- W2034797416 countsByYear W20347974162012 @default.
- W2034797416 countsByYear W20347974162013 @default.
- W2034797416 countsByYear W20347974162015 @default.
- W2034797416 countsByYear W20347974162016 @default.
- W2034797416 countsByYear W20347974162017 @default.
- W2034797416 countsByYear W20347974162020 @default.
- W2034797416 crossrefType "journal-article" @default.
- W2034797416 hasAuthorship W2034797416A5013738913 @default.
- W2034797416 hasAuthorship W2034797416A5022736570 @default.
- W2034797416 hasAuthorship W2034797416A5027806063 @default.
- W2034797416 hasAuthorship W2034797416A5029734068 @default.
- W2034797416 hasAuthorship W2034797416A5046248935 @default.
- W2034797416 hasAuthorship W2034797416A5057072991 @default.
- W2034797416 hasAuthorship W2034797416A5073382503 @default.
- W2034797416 hasConcept C106358424 @default.
- W2034797416 hasConcept C134018914 @default.
- W2034797416 hasConcept C159047783 @default.
- W2034797416 hasConcept C181199279 @default.
- W2034797416 hasConcept C182220744 @default.
- W2034797416 hasConcept C185592680 @default.
- W2034797416 hasConcept C2522874641 @default.
- W2034797416 hasConcept C2776714187 @default.
- W2034797416 hasConcept C2777807008 @default.
- W2034797416 hasConcept C2778937882 @default.
- W2034797416 hasConcept C2780266248 @default.
- W2034797416 hasConcept C3019223276 @default.
- W2034797416 hasConcept C504460877 @default.
- W2034797416 hasConcept C55493867 @default.
- W2034797416 hasConcept C86803240 @default.
- W2034797416 hasConcept C89423630 @default.
- W2034797416 hasConceptScore W2034797416C106358424 @default.
- W2034797416 hasConceptScore W2034797416C134018914 @default.
- W2034797416 hasConceptScore W2034797416C159047783 @default.
- W2034797416 hasConceptScore W2034797416C181199279 @default.
- W2034797416 hasConceptScore W2034797416C182220744 @default.
- W2034797416 hasConceptScore W2034797416C185592680 @default.
- W2034797416 hasConceptScore W2034797416C2522874641 @default.
- W2034797416 hasConceptScore W2034797416C2776714187 @default.
- W2034797416 hasConceptScore W2034797416C2777807008 @default.
- W2034797416 hasConceptScore W2034797416C2778937882 @default.
- W2034797416 hasConceptScore W2034797416C2780266248 @default.
- W2034797416 hasConceptScore W2034797416C3019223276 @default.
- W2034797416 hasConceptScore W2034797416C504460877 @default.
- W2034797416 hasConceptScore W2034797416C55493867 @default.
- W2034797416 hasConceptScore W2034797416C86803240 @default.
- W2034797416 hasConceptScore W2034797416C89423630 @default.
- W2034797416 hasIssue "7" @default.
- W2034797416 hasLocation W20347974161 @default.
- W2034797416 hasLocation W20347974162 @default.
- W2034797416 hasOpenAccess W2034797416 @default.
- W2034797416 hasPrimaryLocation W20347974161 @default.
- W2034797416 hasRelatedWork W17428494 @default.
- W2034797416 hasRelatedWork W2007208290 @default.
- W2034797416 hasRelatedWork W2026960302 @default.
- W2034797416 hasRelatedWork W2034797416 @default.
- W2034797416 hasRelatedWork W2114609271 @default.
- W2034797416 hasRelatedWork W2138942103 @default.
- W2034797416 hasRelatedWork W2139138166 @default.
- W2034797416 hasRelatedWork W2491451478 @default.
- W2034797416 hasRelatedWork W2748811337 @default.
- W2034797416 hasRelatedWork W621019346 @default.
- W2034797416 hasVolume "77" @default.