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• W2034797683 abstract "An unusual oxindole alkaloid inner salt, macrophyllionium (1), and a pair of new tetracyclic oxindole alkaloids, macrophyllines A (2) and B (3), together with six known alkaloids, were isolated from the aerial parts of Uncaria macrophylla. Corynantheidine (8) exhibited moderate cytotoxicity against HL-60 and SW480 cells with IC(50) values of 13.96 and 23.28 μM, respectively. Dihydrocorynantheine (9) exhibited significant vasodilating activity against phenylephrine-induced contraction in rat thoracic aorta rings (IC(50) = 6.73 μg/mL). In addition, compounds 2, 6, and 9 showed weak inhibitory action on KCl-induced contraction." @default.
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• W2034797683 date "2010-11-11" @default.
• W2034797683 modified "2023-10-01" @default.
• W2034797683 title "Macrophyllionium and Macrophyllines A and B, Oxindole Alkaloids from <i>Uncaria macrophylla</i>" @default.
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• W2034797683 doi "https://doi.org/10.1021/np1004938" @default.
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