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• W2034797921 abstract "The diagnosis of Creutzfeldt-Jakob disease (CJD) can only be confirmed by brain biopsy or at necropsy, although a rapidly progressive dementia, myoclonus, other neurological signs, and a characteristic electroencephalogram allows confident ante-mortem diagnosis in typical cases, albeit at a relatively advanced clinical stage. A new clinicopathological type of CJD, new variant CJD (nvCJD) has been reported in the UK and putatively linked on epidemiological grounds with dietary exposure to bovine spongiform encephalopathy (BSE). 1 Will RG Ironside JW Zeidler M et al. A new variant of Creutzfeldt-Jakob disease in the UK. Lancet. 1996; 347: 921-925 Summary PubMed Scopus (1877) Google Scholar Evidence in support of a causal link between BSE and nvCJD is provided by experimental transmission of BSE to macaques, revealing neuropathological similarity to nvCJD, and by the demonstration that nvCJD is associated with a molecular marker that distinguishes it from other forms of CJD and which resembles that seen in BSE and transmitted BSE in a number of other species. 2 Collinge J Sidle KCL Meads J Ironside J Hill AF Molecular analysis of prion stain variation and the aetiology of “new variant” CJD. Nature. 1996; 383: 685-690 Crossref PubMed Scopus (1601) Google Scholar To date, 14 nvCJD cases have been neuropathologically confirmed in the UK and one in France. It is at present unclear how many further cases of nvCJD are likely to appear. In nvCJD, confident diagnosis depends on neuropathology, either from a brain biopsy or at necropsy because the clinical course is atypical and the characteristic electroencephalogram of CJD is absent. 1 Will RG Ironside JW Zeidler M et al. A new variant of Creutzfeldt-Jakob disease in the UK. Lancet. 1996; 347: 921-925 Summary PubMed Scopus (1877) Google Scholar Furthermore, brain biopsy carries a notable morbidity and may give a falsely negative result if the area of brain sampled is unaffected or lacks the specific pathological features of nvCJD. 1 Will RG Ironside JW Zeidler M et al. A new variant of Creutzfeldt-Jakob disease in the UK. Lancet. 1996; 347: 921-925 Summary PubMed Scopus (1877) Google Scholar If nvCJD is caused by BSE, and an epidemic ensures, early diagnostic markers will be essential for differential diagnosis as the presenting clinical features (depression and sensory disturbance) are non-specific and many may be concerned that they have developed this condition. DEPARTMENT OF ERRORGlobal burden of the HIV pandemic—In this article by Quinn (July 13, p 99) the scale of the y axis in the figures for sub-Saharan Africa and Southeast Asia is incorrect. The correct version is shown below. Full-Text PDF" @default.
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• W2034797921 title "Diagnosis of new variant Creutzfeldt-Jakob disease by tonsil biopsy" @default.
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