Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034802107> ?p ?o ?g. }
Showing items 1 to 96 of
96
with 100 items per page.
- W2034802107 endingPage "809" @default.
- W2034802107 startingPage "804" @default.
- W2034802107 abstract "Chronic sinusitis is a common disease characterized by persistent inflammation of the sinus mucosa. This study was undertaken to investigate immunopathologic findings in biopsy specimens from the ethmoid sinuses, maxillary sinuses, and inferior nasal turbinates of 14 allergic subjects with chronic sinusitis. The composition of the inflammatory infiltrate in the three tissue sites was examined by immunocytochemistry with anti‐CD3 (total T cells), anti‐CD4 (helper T cells), anti‐CD8 (suppressor T cells), anti‐MBP (eosinophils), antitryptase (mast cells), and antichymase (mast cells) antibodies. These revealed a significant increase in the T‐cell helper/suppressor ratio and eosinophils in the ethmoid sinus mucosa compared with those in the maxillary sinus mucosa and the inferior turbinate. Eosinophil numbers were also higher in the maxillary sinus than in the inferior turbinate. Mast cells were present in significantly higher numbers in the ethmoid sinus and inferior turbinate biopsy sections than in the maxillary sinus. With antisense, radiolabeled riboprobes, we used in situ hybridization to examine the expression of interleukin‐4 and interleukin‐5 transcripts. The density of cells expressing interleukin‐4 transcripts was significantly higher in the inferior turbinate biopsy sections than in those from the ethmoid and maxillary sinuses. In addition, the number of interleukin‐4 mRNA—positive cells was higher in the ethmoid than in the maxillary sinus mucosa. The density of interleukin‐5 mRNA—positive cells was significantly higher in the ethmoid and maxillary sinuses than in the inferior turbinate. The results of this study indicate (1) a more intense inflammatory response in the ethmoid sinus than in the maxillary sinus and inferior turbinate in allergic chronic sinusitis and (2) different inflammatory responses in the upper airways that are dependent on the anatomic site. These findings have potential implications in the design of new therapeutic interventions for allergic chronic sinusitis. (Otolaryngol Head Neck Surg 1998;118:804–9.)" @default.
- W2034802107 created "2016-06-24" @default.
- W2034802107 creator A5024474336 @default.
- W2034802107 creator A5027127170 @default.
- W2034802107 creator A5028113088 @default.
- W2034802107 creator A5028996231 @default.
- W2034802107 creator A5082060298 @default.
- W2034802107 creator A5083914935 @default.
- W2034802107 date "1998-06-01" @default.
- W2034802107 modified "2023-10-10" @default.
- W2034802107 title "Comparison of Inflammatory Cell Profile and Th2 Cytokine Expression in the Ethmoid Sinuses, Maxillary Sinuses, and Turbinates of Atopic Subjects with Chronic Sinusitis" @default.
- W2034802107 cites W1533977973 @default.
- W2034802107 cites W1982626106 @default.
- W2034802107 cites W2007406607 @default.
- W2034802107 cites W2027242741 @default.
- W2034802107 cites W2034205029 @default.
- W2034802107 cites W2038697551 @default.
- W2034802107 cites W2043614069 @default.
- W2034802107 cites W2050848763 @default.
- W2034802107 cites W2054492502 @default.
- W2034802107 cites W2059357525 @default.
- W2034802107 cites W2080331925 @default.
- W2034802107 cites W2158129229 @default.
- W2034802107 cites W2160572043 @default.
- W2034802107 cites W2476755131 @default.
- W2034802107 doi "https://doi.org/10.1016/s0194-5998(98)70273-6" @default.
- W2034802107 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9627241" @default.
- W2034802107 hasPublicationYear "1998" @default.
- W2034802107 type Work @default.
- W2034802107 sameAs 2034802107 @default.
- W2034802107 citedByCount "36" @default.
- W2034802107 countsByYear W20348021072012 @default.
- W2034802107 countsByYear W20348021072013 @default.
- W2034802107 countsByYear W20348021072014 @default.
- W2034802107 countsByYear W20348021072015 @default.
- W2034802107 countsByYear W20348021072016 @default.
- W2034802107 countsByYear W20348021072018 @default.
- W2034802107 countsByYear W20348021072019 @default.
- W2034802107 countsByYear W20348021072020 @default.
- W2034802107 countsByYear W20348021072021 @default.
- W2034802107 countsByYear W20348021072022 @default.
- W2034802107 crossrefType "journal-article" @default.
- W2034802107 hasAuthorship W2034802107A5024474336 @default.
- W2034802107 hasAuthorship W2034802107A5027127170 @default.
- W2034802107 hasAuthorship W2034802107A5028113088 @default.
- W2034802107 hasAuthorship W2034802107A5028996231 @default.
- W2034802107 hasAuthorship W2034802107A5082060298 @default.
- W2034802107 hasAuthorship W2034802107A5083914935 @default.
- W2034802107 hasConcept C105702510 @default.
- W2034802107 hasConcept C142724271 @default.
- W2034802107 hasConcept C203014093 @default.
- W2034802107 hasConcept C2775934546 @default.
- W2034802107 hasConcept C2776042228 @default.
- W2034802107 hasConcept C2777037409 @default.
- W2034802107 hasConcept C2777768476 @default.
- W2034802107 hasConcept C2777955602 @default.
- W2034802107 hasConcept C2778705571 @default.
- W2034802107 hasConcept C2780732845 @default.
- W2034802107 hasConcept C2994554258 @default.
- W2034802107 hasConcept C59377437 @default.
- W2034802107 hasConcept C71924100 @default.
- W2034802107 hasConceptScore W2034802107C105702510 @default.
- W2034802107 hasConceptScore W2034802107C142724271 @default.
- W2034802107 hasConceptScore W2034802107C203014093 @default.
- W2034802107 hasConceptScore W2034802107C2775934546 @default.
- W2034802107 hasConceptScore W2034802107C2776042228 @default.
- W2034802107 hasConceptScore W2034802107C2777037409 @default.
- W2034802107 hasConceptScore W2034802107C2777768476 @default.
- W2034802107 hasConceptScore W2034802107C2777955602 @default.
- W2034802107 hasConceptScore W2034802107C2778705571 @default.
- W2034802107 hasConceptScore W2034802107C2780732845 @default.
- W2034802107 hasConceptScore W2034802107C2994554258 @default.
- W2034802107 hasConceptScore W2034802107C59377437 @default.
- W2034802107 hasConceptScore W2034802107C71924100 @default.
- W2034802107 hasIssue "6" @default.
- W2034802107 hasLocation W20348021071 @default.
- W2034802107 hasLocation W20348021072 @default.
- W2034802107 hasOpenAccess W2034802107 @default.
- W2034802107 hasPrimaryLocation W20348021071 @default.
- W2034802107 hasRelatedWork W1968003657 @default.
- W2034802107 hasRelatedWork W1997501660 @default.
- W2034802107 hasRelatedWork W2035731801 @default.
- W2034802107 hasRelatedWork W2078493663 @default.
- W2034802107 hasRelatedWork W2274165503 @default.
- W2034802107 hasRelatedWork W2373903365 @default.
- W2034802107 hasRelatedWork W2417914873 @default.
- W2034802107 hasRelatedWork W2468558372 @default.
- W2034802107 hasRelatedWork W2472510569 @default.
- W2034802107 hasRelatedWork W4244381233 @default.
- W2034802107 hasVolume "118" @default.
- W2034802107 isParatext "false" @default.
- W2034802107 isRetracted "false" @default.
- W2034802107 magId "2034802107" @default.
- W2034802107 workType "article" @default.