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• W2034802431 endingPage "61" @default.
• W2034802431 startingPage "59" @default.
• W2034802431 abstract "Human fetus is a natural allograft which survives much longer than any other allograft in an immunologically competent recipient. Namely, semiallogenic trophoblast cells of foetal origin are in intimate contact with mother's decidual mucosa that is abundantly infiltrated by immunocompetent cells. Macrophages are important cytokine producing cells and their number does not change during pregnancy. T lymphocytes are scattered throughout human decidua representing approximately 10-15% of decidual lymphocytes (DL). Decidual large granulated lymphocytes (dLGL) account for about 80% of the total leukocyte population and cause an increase in CD56/CD3 cell ratio to more than 5. Decidual LGL distinct from peripheral blood NK cells. They are CD3-CD16-CD56bright+ with high content of cytolytic mediator-perforin in their granules. The percentage of P+ cells in the suspension of DL is twice higher peripheral blood lymphocytes (PBL) from the same women (55% vs. 27%). However, NK activity of DL is much much lower than NK activity of PBL in spite of the fact that they are full of perforin. The question could be raised as to when and how these cells can be activated? NK cell activity is regulated via signals that are transmitted through killer inhibitory receptor (KIR) and killer activity receptors (KAR). Expression of KIR and absence of CD16 molecules on dLGL are potential mechanism for preventing lysis of trophoblast during normal pregnancy." @default.
• W2034802431 created "2016-06-24" @default.
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• W2034802431 date "1999-04-01" @default.
• W2034802431 modified "2023-09-27" @default.
• W2034802431 title "Immunobiology of reproduction: Role of uniquely abundant NK cells in the placenta" @default.
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• W2034802431 doi "https://doi.org/10.1016/s0197-1859(00)89200-6" @default.
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