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- W2034802437 abstract "The respective examples, described in this paper, illustrate how the BRAFO-tiered approach, on benefit-risk assessment, can be tested on a wide range of case studies. Various results were provided, ranging from a quick stop as the result of non-genuine benefit-risk questions to continuation through the tiers into deterministic/probabilistic calculations. The paper illustrates the assessment of benefits and risks associated with dietary interventions. The BRAFO tiered approach is tested with five case studies. In each instance, the benefit-risk approach is tested on the basis of existing evaluations for the individual effects done by others; no new risk or benefit evaluations were made. The following case studies were thoroughly analysed: an example of food fortification, folic acid fortification of flour, macronutrient replacement/food substitution; the isocaloric replacement of saturated fatty acids with carbohydrates; the replacement of saturated fatty acids with monounsaturated fatty acids; the replacement of sugar-sweetened beverages containing mono- and disaccharides with low calorie sweeteners and an example of addition of specific ingredients to food: chlorination of drinking water." @default.
- W2034802437 created "2016-06-24" @default.
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- W2034802437 date "2012-11-01" @default.
- W2034802437 modified "2023-10-07" @default.
- W2034802437 title "Application of the BRAFO tiered approach for benefit–risk assessment to case studies on dietary interventions" @default.
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- W2034802437 doi "https://doi.org/10.1016/j.fct.2011.06.068" @default.
- W2034802437 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21763387" @default.
- W2034802437 hasPublicationYear "2012" @default.
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