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- W2034802445 abstract "Cronobacter sakazakii (C. sakazakii) is an opportunistic pathogen that causes sepsis and meningitis in neonate. The molecular mechanism involved in the pathogenesis of C. sakazakii meningitis remains unclear. In this study, we found that C. sakazakii invasion was significantly decreased in human brain microvascular endothelial cells (HBMEC) treated with cytosolic phospholipases A2α (cPLA2α) inhibitor. Increased phosphorylation of cPLA2α was observed in HBMEC infected with C. sakazakii, which was prevented by treatment with cPLA2α inhibitor. cPLA2α knockdown in HBMEC significantly attenuated C. sakazakii invasion into HBMEC. Immunofluorescence demonstrated that the rearrangements of actin filaments in HBMEC induced by C. sakazakii were effectively blocked by either treatment with cPLA2α inhibitor or transfection with cPLA2α siRNA. Interestingly, we found that C. sakazakii infection promoted the aggregation of phosphorylated cPLA2α, which was associated with depolymerized actin filaments in HBMEC. Furthermore, our data revealed that cPLA2α acts downstream of Akt signaling pathway in HBMEC stimulated with C. sakazakii. Taken together, our results illustrated that cPLA2α-mediated actin filament rearrangements downstream of Akt activation is required for C. sakazakii invasion into brain endothelial cells." @default.
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- W2034802445 date "2012-01-01" @default.
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- W2034802445 title "cPLA2α-mediated actin rearrangements downstream of the Akt signaling is required for Cronobacter sakazakii invasion into brain endothelial cells" @default.
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- W2034802445 doi "https://doi.org/10.1016/j.bbrc.2011.11.079" @default.
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