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• W2034803116 abstract "The role of Ca 2+ in synaptic vesicle endocytosis remains uncertain due to the diversity in various preparations where several forms of endocytosis may contribute variably in different conditions. Although recent studies have demonstrated that Ca 2+ is important for clathrin-mediated endocytosis (CME), the mechanistic role of Ca 2+ in CME remains to be elucidated. By monitoring CME of single vesicles in mouse chromaffin cells with cell-attached capacitance measurements that offer millisecond time resolution, we demonstrate that the dynamics of vesicle fission during CME is Ca 2+ dependent but becomes Ca 2+ independent in synaptotagmin 1 (Syt1) knock-out cells. Our results thus suggest that Syt1 is necessary for the Ca 2+ dependence of CME." @default.
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• W2034803116 date "2012-03-14" @default.
• W2034803116 modified "2023-10-10" @default.
• W2034803116 title "Synaptotagmin 1 Is Necessary for the Ca²⁺Dependence of Clathrin-Mediated Endocytosis" @default.
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• W2034803116 doi "https://doi.org/10.1523/jneurosci.3540-11.2012" @default.
• W2034803116 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6703464" @default.
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