FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034803380> ?p ?o ?g. }

• W2034803380 endingPage "270" @default.
• W2034803380 startingPage "262" @default.
• W2034803380 abstract "Drugs need to overcome several biological barriers such as the endothelium and cellular membranes in order to reach their target. Promising new therapeutics, many of which are charged and macromolecular, are not able to passively extravasate, let alone cross cell membranes, and stay mainly in the blood pool upon intravenous injection until clearance. Using focused ultrasound (fUS) in combination with circulating microbubbles (MBs) leads to temporary localized tissue permeabilization allowing extravasation of (macro) molecules from the vascular system. Thus, fUS is a promising approach for localized drug delivery. However, little is known about the permeabilization kinetics in skeletal muscle. In this study, we used single photon emission computed tomography (SPECT) to characterize the kinetics of extravasation of 111In-labeled bovine serum albumin (BSA), a model macromolecular drug, in muscle treated with fUS and MBs. The same fUS protocol was applied to 6 groups of mice with different times, ∆t, between fUS application and BSA injection (∆t = − 10, 2.5, 10, 30, 60, 90 min) followed by SPECT imaging. For ∆t ≤ 30 min we observed an exponential accumulation of activity in an area of the treated muscle which extended to a volume larger than the fUS pattern with highest accumulation for short waiting times ∆t. The extent of extravasation decreased exponentially with increasing ∆t, with a calculated half-life of ca. 21 min, defining the time window of extravasation. The same treatment without MBs did not induce extravasation of BSA thus supporting MBs and drug co-injection strategies. These results provide essential information for the development of fUS based strategies for localized drug delivery." @default.
• W2034803380 created "2016-06-24" @default.
• W2034803380 creator A5048066004 @default.
• W2034803380 creator A5053083556 @default.
• W2034803380 creator A5056592812 @default.
• W2034803380 creator A5067050589 @default.
• W2034803380 creator A5073118760 @default.
• W2034803380 date "2013-06-01" @default.
• W2034803380 modified "2023-09-23" @default.
• W2034803380 title "Real-time imaging and kinetics measurements of focused ultrasound-induced extravasation in skeletal muscle using SPECT/CT" @default.
• W2034803380 cites W1974283118 @default.
• W2034803380 cites W1981293537 @default.
• W2034803380 cites W1981391689 @default.
• W2034803380 cites W1986371611 @default.
• W2034803380 cites W1987334539 @default.
• W2034803380 cites W1993077697 @default.
• W2034803380 cites W1993502571 @default.
• W2034803380 cites W1996142593 @default.
• W2034803380 cites W2001455415 @default.
• W2034803380 cites W2002815709 @default.
• W2034803380 cites W2013844718 @default.
• W2034803380 cites W2014840564 @default.
• W2034803380 cites W2021883922 @default.
• W2034803380 cites W2022047477 @default.
• W2034803380 cites W2023780402 @default.
• W2034803380 cites W2023926587 @default.
• W2034803380 cites W2034231369 @default.
• W2034803380 cites W2036426873 @default.
• W2034803380 cites W2040237389 @default.
• W2034803380 cites W2045190338 @default.
• W2034803380 cites W2046582475 @default.
• W2034803380 cites W2046807520 @default.
• W2034803380 cites W2050370670 @default.
• W2034803380 cites W2054885380 @default.
• W2034803380 cites W2055859759 @default.
• W2034803380 cites W2057495360 @default.
• W2034803380 cites W2064531242 @default.
• W2034803380 cites W2068265931 @default.
• W2034803380 cites W2068298462 @default.
• W2034803380 cites W2068597696 @default.
• W2034803380 cites W2069770832 @default.
• W2034803380 cites W2070472280 @default.
• W2034803380 cites W2074093531 @default.
• W2034803380 cites W2074429564 @default.
• W2034803380 cites W2079829796 @default.
• W2034803380 cites W2084645428 @default.
• W2034803380 cites W2088642020 @default.
• W2034803380 cites W2099114210 @default.
• W2034803380 cites W2103361613 @default.
• W2034803380 cites W2105183438 @default.
• W2034803380 cites W2115362657 @default.
• W2034803380 cites W2125394569 @default.
• W2034803380 cites W2125922770 @default.
• W2034803380 cites W2136293998 @default.
• W2034803380 cites W2138766402 @default.
• W2034803380 cites W2166189652 @default.
• W2034803380 cites W2170313716 @default.
• W2034803380 doi "https://doi.org/10.1016/j.jconrel.2013.03.024" @default.
• W2034803380 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23567044" @default.
• W2034803380 hasPublicationYear "2013" @default.
• W2034803380 type Work @default.
• W2034803380 sameAs 2034803380 @default.
• W2034803380 citedByCount "6" @default.
• W2034803380 countsByYear W20348033802013 @default.
• W2034803380 countsByYear W20348033802014 @default.
• W2034803380 countsByYear W20348033802015 @default.
• W2034803380 countsByYear W20348033802018 @default.
• W2034803380 countsByYear W20348033802020 @default.
• W2034803380 crossrefType "journal-article" @default.
• W2034803380 hasAuthorship W2034803380A5048066004 @default.
• W2034803380 hasAuthorship W2034803380A5053083556 @default.
• W2034803380 hasAuthorship W2034803380A5056592812 @default.
• W2034803380 hasAuthorship W2034803380A5067050589 @default.
• W2034803380 hasAuthorship W2034803380A5073118760 @default.
• W2034803380 hasConcept C121332964 @default.
• W2034803380 hasConcept C12554922 @default.
• W2034803380 hasConcept C126838900 @default.
• W2034803380 hasConcept C136229726 @default.
• W2034803380 hasConcept C142724271 @default.
• W2034803380 hasConcept C143753070 @default.
• W2034803380 hasConcept C148898269 @default.
• W2034803380 hasConcept C152900378 @default.
• W2034803380 hasConcept C170493617 @default.
• W2034803380 hasConcept C178790620 @default.
• W2034803380 hasConcept C185592680 @default.
• W2034803380 hasConcept C2779540182 @default.
• W2034803380 hasConcept C2779820397 @default.
• W2034803380 hasConcept C55493867 @default.
• W2034803380 hasConcept C62520636 @default.
• W2034803380 hasConcept C64012434 @default.
• W2034803380 hasConcept C71924100 @default.
• W2034803380 hasConcept C86803240 @default.
• W2034803380 hasConceptScore W2034803380C121332964 @default.
• W2034803380 hasConceptScore W2034803380C12554922 @default.
• W2034803380 hasConceptScore W2034803380C126838900 @default.
• W2034803380 hasConceptScore W2034803380C136229726 @default.
• W2034803380 hasConceptScore W2034803380C142724271 @default.
• W2034803380 hasConceptScore W2034803380C143753070 @default.

• next