FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034803757> ?p ?o ?g. }

• W2034803757 endingPage "148" @default.
• W2034803757 startingPage "143" @default.
• W2034803757 abstract "Up to 30% of patients with low-risk prostate cancer (PCa) are found to have features of aggressive disease at radical prostatectomy (RP). Several predictive nomograms and novel genomic markers have been developed to estimate the risk of adverse pathology in men eligible for active surveillance (AS). However, oncologic risk associated with these findings remains unknown.To determine if the presence of adverse pathologic features at RP in patients eligible for AS is prognostic of poor oncologic outcome independent of pretreatment risk status.A total of 2660 patients underwent immediate RP at our institution between 1998 and 2008. Patients were stratified as low, intermediate, or high risk according to the D'Amico clinical risk criteria.The rates of adverse pathology were reported, and the 5-yr risk of biochemical recurrence (BCR) was calculated in the presence of aggressive disease.The 5-yr risk of BCR in patients with extracapsular extension (n=937) was 43% (95% confidence interval [CI], 40-46) overall but only 15% (95% CI, 11-22) for those who met the criteria for low risk (n=181). For the 473 patients with pathologic Gleason score 4+3, the risk of recurrence at 5 yr was 41% (95% CI, 37-46) overall, 13% (95% CI, 5-27) for low-risk men (n=41), 41% (95% CI, 35-47) for intermediate-risk men (n=287), and 51% (95% CI, 43-60) for high-risk men (n=145). Limitations include use of BCR as the study end point and surrogate for oncologic outcome in men who received curative treatment.The presence of pathologically unfavorable disease in patients eligible for AS is not informative as to the safety of this treatment modality. We question the relevance of adverse pathology as the end point for predictive tools designed to guide treatment decisions in low-risk PCa.The risk of biochemical recurrence associated with adverse pathologic findings at prostatectomy is reduced by approximately 50% in men with clinically low-risk prostate cancer." @default.
• W2034803757 created "2016-06-24" @default.
• W2034803757 creator A5008906321 @default.
• W2034803757 creator A5035902985 @default.
• W2034803757 creator A5052299820 @default.
• W2034803757 date "2016-01-01" @default.
• W2034803757 modified "2023-10-02" @default.
• W2034803757 title "Adverse Pathologic Features at Radical Prostatectomy: Effect of Preoperative Risk on Oncologic Outcomes" @default.
• W2034803757 cites W1484814684 @default.
• W2034803757 cites W1519924883 @default.
• W2034803757 cites W1975689368 @default.
• W2034803757 cites W1990546987 @default.
• W2034803757 cites W2035765716 @default.
• W2034803757 cites W2039529553 @default.
• W2034803757 cites W2040659915 @default.
• W2034803757 cites W2045216565 @default.
• W2034803757 cites W2052448382 @default.
• W2034803757 cites W2053948486 @default.
• W2034803757 cites W2071879495 @default.
• W2034803757 cites W2083043726 @default.
• W2034803757 cites W2088047624 @default.
• W2034803757 cites W2101889062 @default.
• W2034803757 cites W2117792530 @default.
• W2034803757 cites W2121655616 @default.
• W2034803757 cites W2123275337 @default.
• W2034803757 cites W2130614544 @default.
• W2034803757 cites W2131357804 @default.
• W2034803757 cites W2151494814 @default.
• W2034803757 cites W2158099560 @default.
• W2034803757 cites W2160217483 @default.
• W2034803757 cites W2168133848 @default.
• W2034803757 cites W3023689102 @default.
• W2034803757 doi "https://doi.org/10.1016/j.eururo.2015.03.044" @default.
• W2034803757 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4618775" @default.
• W2034803757 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25913389" @default.
• W2034803757 hasPublicationYear "2016" @default.
• W2034803757 type Work @default.
• W2034803757 sameAs 2034803757 @default.
• W2034803757 citedByCount "51" @default.
• W2034803757 countsByYear W20348037572016 @default.
• W2034803757 countsByYear W20348037572017 @default.
• W2034803757 countsByYear W20348037572018 @default.
• W2034803757 countsByYear W20348037572019 @default.
• W2034803757 countsByYear W20348037572020 @default.
• W2034803757 countsByYear W20348037572021 @default.
• W2034803757 countsByYear W20348037572022 @default.
• W2034803757 countsByYear W20348037572023 @default.
• W2034803757 crossrefType "journal-article" @default.
• W2034803757 hasAuthorship W2034803757A5008906321 @default.
• W2034803757 hasAuthorship W2034803757A5035902985 @default.
• W2034803757 hasAuthorship W2034803757A5052299820 @default.
• W2034803757 hasBestOaLocation W20348037572 @default.
• W2034803757 hasConcept C121608353 @default.
• W2034803757 hasConcept C12174686 @default.
• W2034803757 hasConcept C126322002 @default.
• W2034803757 hasConcept C126894567 @default.
• W2034803757 hasConcept C141071460 @default.
• W2034803757 hasConcept C197934379 @default.
• W2034803757 hasConcept C2776141087 @default.
• W2034803757 hasConcept C2777008409 @default.
• W2034803757 hasConcept C2779466945 @default.
• W2034803757 hasConcept C2780192828 @default.
• W2034803757 hasConcept C34626388 @default.
• W2034803757 hasConcept C38652104 @default.
• W2034803757 hasConcept C41008148 @default.
• W2034803757 hasConcept C44249647 @default.
• W2034803757 hasConcept C71924100 @default.
• W2034803757 hasConceptScore W2034803757C121608353 @default.
• W2034803757 hasConceptScore W2034803757C12174686 @default.
• W2034803757 hasConceptScore W2034803757C126322002 @default.
• W2034803757 hasConceptScore W2034803757C126894567 @default.
• W2034803757 hasConceptScore W2034803757C141071460 @default.
• W2034803757 hasConceptScore W2034803757C197934379 @default.
• W2034803757 hasConceptScore W2034803757C2776141087 @default.
• W2034803757 hasConceptScore W2034803757C2777008409 @default.
• W2034803757 hasConceptScore W2034803757C2779466945 @default.
• W2034803757 hasConceptScore W2034803757C2780192828 @default.
• W2034803757 hasConceptScore W2034803757C34626388 @default.
• W2034803757 hasConceptScore W2034803757C38652104 @default.
• W2034803757 hasConceptScore W2034803757C41008148 @default.
• W2034803757 hasConceptScore W2034803757C44249647 @default.
• W2034803757 hasConceptScore W2034803757C71924100 @default.
• W2034803757 hasIssue "1" @default.
• W2034803757 hasLocation W20348037571 @default.
• W2034803757 hasLocation W20348037572 @default.
• W2034803757 hasLocation W20348037573 @default.
• W2034803757 hasLocation W20348037574 @default.
• W2034803757 hasOpenAccess W2034803757 @default.
• W2034803757 hasPrimaryLocation W20348037571 @default.
• W2034803757 hasRelatedWork W1967410728 @default.
• W2034803757 hasRelatedWork W2025979791 @default.
• W2034803757 hasRelatedWork W2026113581 @default.
• W2034803757 hasRelatedWork W2050947211 @default.
• W2034803757 hasRelatedWork W2123702677 @default.
• W2034803757 hasRelatedWork W2133978084 @default.
• W2034803757 hasRelatedWork W2172257731 @default.
• W2034803757 hasRelatedWork W2223028031 @default.
• W2034803757 hasRelatedWork W3150909901 @default.

• next