FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034803902> ?p ?o ?g. }

• W2034803902 endingPage "4294" @default.
• W2034803902 startingPage "4284" @default.
• W2034803902 abstract "The V3 loop is part of the gp120 glycoprotein, an extracellular protein located on the membrane of the human immunodeficiency virus (HIV-1). This loop is significantly important in many biological processes of the virus and contains the principal neutralizing determinant (PND). The PND is one of the most variable regions of the envelope, and this is probably related to the ability of the HIV virus to escape the immunologic defenses of the target host. Particular attention has been paid to the central part of the V3 loop which contains a highly conserved GPGR/GPGQ sequence and represents the binding site for antibodies. Many attempts have been made to design synthetic peptides as mimics of the V3 loop capable of eliciting immune response. However, this strategy suffers from the great conformational flexibility small peptides have in solution, which together with bioavailability represents the most important limitation to the usefulness of synthetic peptides as drugs and as synthetic immunogens. The use of conformationally constrained peptides can alleviate this problem. Early works using NMR studies have shown that a V3IIIB loop-derived peptide is conformationally heterogeneous when free in water. Upon complexation with 0.5β, a monoclonal neutralizing antibody specific for the HIV-1IIIB strain, it adopts a β-hairpin conformation with the central proline forming a type VIb β-turn. In this study, we report the design and characterization of a conformationally restricted peptide with a sequence identical to that previously described, but with thiazolidine derivatives replacing the proline. The affinity of the 2,2-dimethylthiazolidine derivative for 0.5β demonstrates that this moiety can successfully be used to mimic the proline in a cis conformation. This peptide not only displays a high propensity to adopt a β-hairpin conformation but also retains the type VIb RGPG β-turn similar to that found in the native complex. These compounds could help in elaborating more efficient immunogens for HIV-1 synthetic vaccine development." @default.
• W2034803902 created "2016-06-24" @default.
• W2034803902 creator A5000847014 @default.
• W2034803902 creator A5021094489 @default.
• W2034803902 creator A5075602639 @default.
• W2034803902 creator A5091212681 @default.
• W2034803902 date "2006-03-09" @default.
• W2034803902 modified "2023-09-24" @default.
• W2034803902 title "Stabilization of the Biologically Active Conformation of the Principal Neutralizing Determinant of HIV-1_IIIBContaining a<i>cis</i>-Proline Surrogate: ¹H NMR and Molecular Modeling Study" @default.
• W2034803902 cites W1568767105 @default.
• W2034803902 cites W1603139909 @default.
• W2034803902 cites W1817018401 @default.
• W2034803902 cites W1964659291 @default.
• W2034803902 cites W1990959282 @default.
• W2034803902 cites W1995092400 @default.
• W2034803902 cites W2003802570 @default.
• W2034803902 cites W2008012729 @default.
• W2034803902 cites W2010258400 @default.
• W2034803902 cites W2015835250 @default.
• W2034803902 cites W2021102059 @default.
• W2034803902 cites W2027720097 @default.
• W2034803902 cites W2067300620 @default.
• W2034803902 cites W2068131424 @default.
• W2034803902 cites W2074770586 @default.
• W2034803902 cites W2076755375 @default.
• W2034803902 cites W2099535895 @default.
• W2034803902 cites W2104426843 @default.
• W2034803902 cites W2147169218 @default.
• W2034803902 cites W2149227294 @default.
• W2034803902 cites W2151124114 @default.
• W2034803902 cites W2949250147 @default.
• W2034803902 cites W4242009576 @default.
• W2034803902 doi "https://doi.org/10.1021/bi052615k" @default.
• W2034803902 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16566603" @default.
• W2034803902 hasPublicationYear "2006" @default.
• W2034803902 type Work @default.
• W2034803902 sameAs 2034803902 @default.
• W2034803902 citedByCount "7" @default.
• W2034803902 countsByYear W20348039022014 @default.
• W2034803902 countsByYear W20348039022015 @default.
• W2034803902 countsByYear W20348039022019 @default.
• W2034803902 crossrefType "journal-article" @default.
• W2034803902 hasAuthorship W2034803902A5000847014 @default.
• W2034803902 hasAuthorship W2034803902A5021094489 @default.
• W2034803902 hasAuthorship W2034803902A5075602639 @default.
• W2034803902 hasAuthorship W2034803902A5091212681 @default.
• W2034803902 hasConcept C104317684 @default.
• W2034803902 hasConcept C159654299 @default.
• W2034803902 hasConcept C167625842 @default.
• W2034803902 hasConcept C185592680 @default.
• W2034803902 hasConcept C195616568 @default.
• W2034803902 hasConcept C203014093 @default.
• W2034803902 hasConcept C2776258796 @default.
• W2034803902 hasConcept C2779281246 @default.
• W2034803902 hasConcept C2779921545 @default.
• W2034803902 hasConcept C55493867 @default.
• W2034803902 hasConcept C71240020 @default.
• W2034803902 hasConcept C86803240 @default.
• W2034803902 hasConceptScore W2034803902C104317684 @default.
• W2034803902 hasConceptScore W2034803902C159654299 @default.
• W2034803902 hasConceptScore W2034803902C167625842 @default.
• W2034803902 hasConceptScore W2034803902C185592680 @default.
• W2034803902 hasConceptScore W2034803902C195616568 @default.
• W2034803902 hasConceptScore W2034803902C203014093 @default.
• W2034803902 hasConceptScore W2034803902C2776258796 @default.
• W2034803902 hasConceptScore W2034803902C2779281246 @default.
• W2034803902 hasConceptScore W2034803902C2779921545 @default.
• W2034803902 hasConceptScore W2034803902C55493867 @default.
• W2034803902 hasConceptScore W2034803902C71240020 @default.
• W2034803902 hasConceptScore W2034803902C86803240 @default.
• W2034803902 hasIssue "13" @default.
• W2034803902 hasLocation W20348039021 @default.
• W2034803902 hasLocation W20348039022 @default.
• W2034803902 hasOpenAccess W2034803902 @default.
• W2034803902 hasPrimaryLocation W20348039021 @default.
• W2034803902 hasRelatedWork W1571667441 @default.
• W2034803902 hasRelatedWork W1978045911 @default.
• W2034803902 hasRelatedWork W2003425309 @default.
• W2034803902 hasRelatedWork W2009031499 @default.
• W2034803902 hasRelatedWork W2028009816 @default.
• W2034803902 hasRelatedWork W2045194709 @default.
• W2034803902 hasRelatedWork W2082071030 @default.
• W2034803902 hasRelatedWork W2113164746 @default.
• W2034803902 hasRelatedWork W2147898271 @default.
• W2034803902 hasRelatedWork W2978378252 @default.
• W2034803902 hasVolume "45" @default.
• W2034803902 isParatext "false" @default.
• W2034803902 isRetracted "false" @default.
• W2034803902 magId "2034803902" @default.
• W2034803902 workType "article" @default.