FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034804512> ?p ?o ?g. }

• W2034804512 abstract "Vertebrate vision requires photon absorption by photoreceptor outer segments (OSs), structurally elaborate membranous organelles derived from non-motile sensory cilia. OS structure/function depends on a precise stacking of hundreds of membranous disks. Each disk is fully (as in rods) or partially (as in cones) bounded by a rim, at which the membrane is distorted into an energetically unfavorable high curvature bend; however, the mechanism(s) underlying disk rim structure are not established. Here we demonstrate that the intrinsically disordered cytoplasmic C-terminus of the photoreceptor tetraspanin peripherin-2/rds (P/rds) can directly generate membrane curvature. A P/rds C-terminal domain (CTER) and a peptide mimetic of an amphipathic helix (AH) contained within it (CHR) each generated curvature in liposomes with a composition similar to that of OS disks and in liposomes generated from native OS lipids. CTER association with liposomes required conical phospholipids, and was promoted by membrane curvature and anionic surface charge, results suggesting that the P/rds C-terminal AH can partition into the cytosolic membrane leaflet to generate curvature via a hydrophobic insertion (wedging) mechanism. This activity was evidenced in full-length P/rds by its induction of small diameter tubulovesicular membrane foci in cultured cells. In sum, the findings suggest that curvature generation by the P/rds C-terminus may contribute to the distinctive structure of OS disk rims, and provide insight into how inherited defects in P/rds can disrupt organelle structure to cause retinal disease. They also raise the possibility that tethered AHs can function for shaping cellular membranes more generally." @default.
• W2034804512 created "2016-06-24" @default.
• W2034804512 creator A5015547003 @default.
• W2034804512 creator A5019874131 @default.
• W2034804512 creator A5038074511 @default.
• W2034804512 date "2013-01-01" @default.
• W2034804512 modified "2023-09-27" @default.
• W2034804512 title "Membrane curvature generation by a C-terminal amphipathic helix in peripherin-2/rds, a tetraspanin required for photoreceptor sensory cilium morphogenesis" @default.
• W2034804512 cites W1026154262 @default.
• W2034804512 cites W1492612217 @default.
• W2034804512 cites W1513897103 @default.
• W2034804512 cites W1546944826 @default.
• W2034804512 cites W1590141349 @default.
• W2034804512 cites W1967942686 @default.
• W2034804512 cites W1972162380 @default.
• W2034804512 cites W1978063480 @default.
• W2034804512 cites W1978516234 @default.
• W2034804512 cites W1979291207 @default.
• W2034804512 cites W1980805294 @default.
• W2034804512 cites W1984250381 @default.
• W2034804512 cites W1985962112 @default.
• W2034804512 cites W1987644884 @default.
• W2034804512 cites W1987835269 @default.
• W2034804512 cites W1989479561 @default.
• W2034804512 cites W1991803711 @default.
• W2034804512 cites W1996355353 @default.
• W2034804512 cites W1998533469 @default.
• W2034804512 cites W1999713448 @default.
• W2034804512 cites W2000232627 @default.
• W2034804512 cites W2000429226 @default.
• W2034804512 cites W2004014468 @default.
• W2034804512 cites W2007290619 @default.
• W2034804512 cites W2011633921 @default.
• W2034804512 cites W2024263951 @default.
• W2034804512 cites W2029347326 @default.
• W2034804512 cites W2030924644 @default.
• W2034804512 cites W2032338309 @default.
• W2034804512 cites W2032452363 @default.
• W2034804512 cites W2033852655 @default.
• W2034804512 cites W2035697025 @default.
• W2034804512 cites W2039447559 @default.
• W2034804512 cites W2043288164 @default.
• W2034804512 cites W2055989493 @default.
• W2034804512 cites W2056922888 @default.
• W2034804512 cites W2057629508 @default.
• W2034804512 cites W2058917275 @default.
• W2034804512 cites W2059671927 @default.
• W2034804512 cites W2063636670 @default.
• W2034804512 cites W2066780072 @default.
• W2034804512 cites W2068913774 @default.
• W2034804512 cites W2069903667 @default.
• W2034804512 cites W2072167784 @default.
• W2034804512 cites W2074202884 @default.
• W2034804512 cites W2077136636 @default.
• W2034804512 cites W2080904282 @default.
• W2034804512 cites W2083258595 @default.
• W2034804512 cites W2085374398 @default.
• W2034804512 cites W2086470900 @default.
• W2034804512 cites W2089643622 @default.
• W2034804512 cites W2091521215 @default.
• W2034804512 cites W2094117679 @default.
• W2034804512 cites W2106333373 @default.
• W2034804512 cites W2108788043 @default.
• W2034804512 cites W2110829301 @default.
• W2034804512 cites W2114628856 @default.
• W2034804512 cites W2119993590 @default.
• W2034804512 cites W2121822849 @default.
• W2034804512 cites W2123814643 @default.
• W2034804512 cites W2127234404 @default.
• W2034804512 cites W2134996138 @default.
• W2034804512 cites W2149694036 @default.
• W2034804512 cites W2149981823 @default.
• W2034804512 cites W2157542919 @default.
• W2034804512 cites W2162478996 @default.
• W2034804512 cites W2168526937 @default.
• W2034804512 cites W2411368169 @default.
• W2034804512 cites W4251321628 @default.
• W2034804512 cites W87971946 @default.
• W2034804512 doi "https://doi.org/10.1242/jcs.126888" @default.
• W2034804512 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3795338" @default.
• W2034804512 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23886945" @default.
• W2034804512 hasPublicationYear "2013" @default.
• W2034804512 type Work @default.
• W2034804512 sameAs 2034804512 @default.
• W2034804512 citedByCount "41" @default.
• W2034804512 countsByYear W20348045122014 @default.
• W2034804512 countsByYear W20348045122015 @default.
• W2034804512 countsByYear W20348045122016 @default.
• W2034804512 countsByYear W20348045122017 @default.
• W2034804512 countsByYear W20348045122018 @default.
• W2034804512 countsByYear W20348045122019 @default.
• W2034804512 countsByYear W20348045122020 @default.
• W2034804512 countsByYear W20348045122022 @default.
• W2034804512 crossrefType "journal-article" @default.
• W2034804512 hasAuthorship W2034804512A5015547003 @default.
• W2034804512 hasAuthorship W2034804512A5019874131 @default.
• W2034804512 hasAuthorship W2034804512A5038074511 @default.
• W2034804512 hasBestOaLocation W20348045121 @default.
• W2034804512 hasConcept C100094513 @default.
• W2034804512 hasConcept C104317684 @default.

• next