FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034804666> ?p ?o ?g. }

• W2034804666 endingPage "1240" @default.
• W2034804666 startingPage "1229" @default.
• W2034804666 abstract "We have previously demonstrated that L-triiodothyronine (L-T3) induces an increase in growth hormone synthesis and messenger RNA in cultured GH1 cells, a rat pituitary cell line. In addition to regulating the growth hormone response, L-T3 elicits a time- and dose-dependent reduction in the level of its nuclear receptor, which is a direct function of the occupancy of the receptor binding site. In this study we have compared the relative affinity of L-T3, triiodothyroacetic acid, D-triiodothyronine (D-T3), and L-thyroxine (L-T4) for the receptor with the induction of the growth hormone synthesis and the ability of these compounds to elicit a reduction in thyroid hormone nuclear receptor levels. Triiodothyroacetic acid and D-T3 were specifically examined because the biologic effect of these compounds in the intact rat is significantly lower than predicted by their affinity for the receptor using isolated rat liver nuclei in vitro. In intact cells each compound demonstrated an excellent relationship between the relative receptor affinity, the induction of growth hormone production, and the concentration-dependent reduction in nuclear receptor levels. With the exception of D-T3, the relative affinity of iodothyronine was identical for the receptor using intact cells in serum-free media, or isolated GH1 cell nuclei in vitro. The apparent receptor affinity of D-T3 with intact cells was 5.5-fold lower than with isolated nuclei, which suggests a decrease in cell entry of D-T3 relative to the other iodothyronines. Quantitation of the [125I]iodothyronine associated with the receptor in GH1 cells after a 36-h incubation with L-125I-T4 was 90% L-T4 and 10% L-T3, which indicates that the major effect of L-T4 in GH1 cells is a result of intrinsic L-T4 activity. Studies with dispersed rat anterior pituitary cells demonstrated that L-T3 induces growth hormone synthesis and elicits a reduction in nuclear receptor levels in the same fashion as GH1 cells. The observation that thyroid hormone influences dispersed rat pituitary cells in a fashion qualitatively similar to GH1 cells may have implications for the growth hormone response of the somatotroph cell in vivo to different thyroidal states." @default.
• W2034804666 created "2016-06-24" @default.
• W2034804666 creator A5006192791 @default.
• W2034804666 creator A5014222482 @default.
• W2034804666 creator A5015325500 @default.
• W2034804666 date "1979-06-01" @default.
• W2034804666 modified "2023-09-26" @default.
• W2034804666 title "Relationship of receptor affinity to the modulation of thyroid hormone nuclear receptor levels and growth hormone synthesis by L-triiodothyronine and iodothyronine analogues in cultured GH1 cells." @default.
• W2034804666 cites W1516206119 @default.
• W2034804666 cites W1565068678 @default.
• W2034804666 cites W1599658955 @default.
• W2034804666 cites W1775749144 @default.
• W2034804666 cites W1906197854 @default.
• W2034804666 cites W1963900949 @default.
• W2034804666 cites W1965163118 @default.
• W2034804666 cites W1965470204 @default.
• W2034804666 cites W1968687287 @default.
• W2034804666 cites W1970286542 @default.
• W2034804666 cites W1970895519 @default.
• W2034804666 cites W1974407367 @default.
• W2034804666 cites W1979392504 @default.
• W2034804666 cites W1979544459 @default.
• W2034804666 cites W1984505489 @default.
• W2034804666 cites W1985956676 @default.
• W2034804666 cites W1986844525 @default.
• W2034804666 cites W1997423200 @default.
• W2034804666 cites W1998995392 @default.
• W2034804666 cites W1999185499 @default.
• W2034804666 cites W2012966827 @default.
• W2034804666 cites W2014579000 @default.
• W2034804666 cites W2025433728 @default.
• W2034804666 cites W2025471166 @default.
• W2034804666 cites W2026242312 @default.
• W2034804666 cites W2027272877 @default.
• W2034804666 cites W2027340926 @default.
• W2034804666 cites W2028877309 @default.
• W2034804666 cites W2033724986 @default.
• W2034804666 cites W2059324009 @default.
• W2034804666 cites W2063368059 @default.
• W2034804666 cites W2065376771 @default.
• W2034804666 cites W2066958968 @default.
• W2034804666 cites W2071132311 @default.
• W2034804666 cites W2074172527 @default.
• W2034804666 cites W2085940870 @default.
• W2034804666 cites W2106173832 @default.
• W2034804666 cites W2131858544 @default.
• W2034804666 cites W2140340472 @default.
• W2034804666 cites W2140585089 @default.
• W2034804666 cites W2154742909 @default.
• W2034804666 cites W2162073688 @default.
• W2034804666 cites W2171860651 @default.
• W2034804666 cites W2201417858 @default.
• W2034804666 cites W2405476581 @default.
• W2034804666 cites W2419377870 @default.
• W2034804666 cites W2616781818 @default.
• W2034804666 doi "https://doi.org/10.1172/jci109418" @default.
• W2034804666 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/372072" @default.
• W2034804666 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/221536" @default.
• W2034804666 hasPublicationYear "1979" @default.
• W2034804666 type Work @default.
• W2034804666 sameAs 2034804666 @default.
• W2034804666 citedByCount "122" @default.
• W2034804666 countsByYear W20348046662013 @default.
• W2034804666 countsByYear W20348046662014 @default.
• W2034804666 countsByYear W20348046662015 @default.
• W2034804666 countsByYear W20348046662017 @default.
• W2034804666 countsByYear W20348046662018 @default.
• W2034804666 countsByYear W20348046662020 @default.
• W2034804666 countsByYear W20348046662021 @default.
• W2034804666 crossrefType "journal-article" @default.
• W2034804666 hasAuthorship W2034804666A5006192791 @default.
• W2034804666 hasAuthorship W2034804666A5014222482 @default.
• W2034804666 hasAuthorship W2034804666A5015325500 @default.
• W2034804666 hasBestOaLocation W20348046661 @default.
• W2034804666 hasConcept C104317684 @default.
• W2034804666 hasConcept C109115496 @default.
• W2034804666 hasConcept C121608353 @default.
• W2034804666 hasConcept C126322002 @default.
• W2034804666 hasConcept C134018914 @default.
• W2034804666 hasConcept C149574134 @default.
• W2034804666 hasConcept C160860887 @default.
• W2034804666 hasConcept C170493617 @default.
• W2034804666 hasConcept C202751555 @default.
• W2034804666 hasConcept C23589133 @default.
• W2034804666 hasConcept C2778288131 @default.
• W2034804666 hasConcept C530470458 @default.
• W2034804666 hasConcept C55493867 @default.
• W2034804666 hasConcept C63932345 @default.
• W2034804666 hasConcept C71315377 @default.
• W2034804666 hasConcept C71924100 @default.
• W2034804666 hasConcept C86339819 @default.
• W2034804666 hasConcept C86803240 @default.
• W2034804666 hasConceptScore W2034804666C104317684 @default.
• W2034804666 hasConceptScore W2034804666C109115496 @default.
• W2034804666 hasConceptScore W2034804666C121608353 @default.
• W2034804666 hasConceptScore W2034804666C126322002 @default.
• W2034804666 hasConceptScore W2034804666C134018914 @default.
• W2034804666 hasConceptScore W2034804666C149574134 @default.

• next