FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034804703> ?p ?o ?g. }

• W2034804703 endingPage "6408" @default.
• W2034804703 startingPage "6401" @default.
• W2034804703 abstract "Neuronal cell death occurs during many neurodegenerative disorders and stroke. The aberrant, excessive activity of matrix metalloproteinases (MMPs), especially MMP-9, contributes directly to neuron apoptosis and brain damage (Rosenberg et al., 1996; Asahi et al., 2001; Gu et al., 2002; Horstmann et al., 2003). We determined that MMP-9 degrades the extracellular matrix protein laminin and that this degradation induces neuronal apoptosis in a transient focal cerebral ischemia model in mice. We also determined that the highly specific thiirane gelatinase inhibitor SB-3CT blocks MMP-9 activity, including MMP-9-mediated laminin cleavage, thus rescuing neurons from apoptosis. We conclude that MMP-9 is a highly promising drug target and that SB-3CT derivatives have significant therapeutic potential in stroke patients." @default.
• W2034804703 created "2016-06-24" @default.
• W2034804703 creator A5013154347 @default.
• W2034804703 creator A5013812375 @default.
• W2034804703 creator A5029138795 @default.
• W2034804703 creator A5062429074 @default.
• W2034804703 creator A5063462261 @default.
• W2034804703 creator A5066753734 @default.
• W2034804703 creator A5081561177 @default.
• W2034804703 date "2005-07-06" @default.
• W2034804703 modified "2023-10-14" @default.
• W2034804703 title "A Highly Specific Inhibitor of Matrix Metalloproteinase-9 Rescues Laminin from Proteolysis and Neurons from Apoptosis in Transient Focal Cerebral Ischemia" @default.
• W2034804703 cites W1619234695 @default.
• W2034804703 cites W1771562684 @default.
• W2034804703 cites W1955736456 @default.
• W2034804703 cites W1978837916 @default.
• W2034804703 cites W1983401409 @default.
• W2034804703 cites W1984483611 @default.
• W2034804703 cites W1984801123 @default.
• W2034804703 cites W1990711278 @default.
• W2034804703 cites W1992218027 @default.
• W2034804703 cites W1996802760 @default.
• W2034804703 cites W2013662783 @default.
• W2034804703 cites W2022655834 @default.
• W2034804703 cites W2033341544 @default.
• W2034804703 cites W2034806037 @default.
• W2034804703 cites W2043810400 @default.
• W2034804703 cites W2043949364 @default.
• W2034804703 cites W2046329404 @default.
• W2034804703 cites W2048047884 @default.
• W2034804703 cites W2070543132 @default.
• W2034804703 cites W2086386772 @default.
• W2034804703 cites W2097510913 @default.
• W2034804703 cites W2101189183 @default.
• W2034804703 cites W2113892795 @default.
• W2034804703 cites W2123648780 @default.
• W2034804703 cites W2137022580 @default.
• W2034804703 cites W2139647613 @default.
• W2034804703 cites W2156474637 @default.
• W2034804703 cites W2292308933 @default.
• W2034804703 cites W4296234323 @default.
• W2034804703 doi "https://doi.org/10.1523/jneurosci.1563-05.2005" @default.
• W2034804703 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6725288" @default.
• W2034804703 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16000631" @default.
• W2034804703 hasPublicationYear "2005" @default.
• W2034804703 type Work @default.
• W2034804703 sameAs 2034804703 @default.
• W2034804703 citedByCount "382" @default.
• W2034804703 countsByYear W20348047032012 @default.
• W2034804703 countsByYear W20348047032013 @default.
• W2034804703 countsByYear W20348047032014 @default.
• W2034804703 countsByYear W20348047032015 @default.
• W2034804703 countsByYear W20348047032016 @default.
• W2034804703 countsByYear W20348047032017 @default.
• W2034804703 countsByYear W20348047032018 @default.
• W2034804703 countsByYear W20348047032019 @default.
• W2034804703 countsByYear W20348047032020 @default.
• W2034804703 countsByYear W20348047032021 @default.
• W2034804703 countsByYear W20348047032022 @default.
• W2034804703 countsByYear W20348047032023 @default.
• W2034804703 crossrefType "journal-article" @default.
• W2034804703 hasAuthorship W2034804703A5013154347 @default.
• W2034804703 hasAuthorship W2034804703A5013812375 @default.
• W2034804703 hasAuthorship W2034804703A5029138795 @default.
• W2034804703 hasAuthorship W2034804703A5062429074 @default.
• W2034804703 hasAuthorship W2034804703A5063462261 @default.
• W2034804703 hasAuthorship W2034804703A5066753734 @default.
• W2034804703 hasAuthorship W2034804703A5081561177 @default.
• W2034804703 hasBestOaLocation W20348047031 @default.
• W2034804703 hasConcept C109523444 @default.
• W2034804703 hasConcept C126322002 @default.
• W2034804703 hasConcept C169760540 @default.
• W2034804703 hasConcept C181199279 @default.
• W2034804703 hasConcept C185592680 @default.
• W2034804703 hasConcept C189165786 @default.
• W2034804703 hasConcept C190283241 @default.
• W2034804703 hasConcept C2778820722 @default.
• W2034804703 hasConcept C2779814568 @default.
• W2034804703 hasConcept C2781307694 @default.
• W2034804703 hasConcept C31573885 @default.
• W2034804703 hasConcept C541997718 @default.
• W2034804703 hasConcept C55493867 @default.
• W2034804703 hasConcept C71924100 @default.
• W2034804703 hasConcept C86803240 @default.
• W2034804703 hasConcept C95444343 @default.
• W2034804703 hasConceptScore W2034804703C109523444 @default.
• W2034804703 hasConceptScore W2034804703C126322002 @default.
• W2034804703 hasConceptScore W2034804703C169760540 @default.
• W2034804703 hasConceptScore W2034804703C181199279 @default.
• W2034804703 hasConceptScore W2034804703C185592680 @default.
• W2034804703 hasConceptScore W2034804703C189165786 @default.
• W2034804703 hasConceptScore W2034804703C190283241 @default.
• W2034804703 hasConceptScore W2034804703C2778820722 @default.
• W2034804703 hasConceptScore W2034804703C2779814568 @default.
• W2034804703 hasConceptScore W2034804703C2781307694 @default.
• W2034804703 hasConceptScore W2034804703C31573885 @default.
• W2034804703 hasConceptScore W2034804703C541997718 @default.
• W2034804703 hasConceptScore W2034804703C55493867 @default.

• next