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- W2034805757 abstract "To evaluate the need for creatine and phosphocreatine in the maintenance of muscle fiber size, the effects of chronic depletion of these compounds were studied. Mice were fed a Chow diet containing 1% β-guanidinopropionic acid (β-GPA) to deplete skeletal muscle of creatine and phosphocreatine. β-GPA is a specific, competitive inhibitor of creatine transport across biological membranes. On this diet, the creatine concentration in tibialis anterior muscles decreased from 11.0 ± 3.6 (mean ± SD) to 3.7 ± 1.3 μmol wet weight, the phosphocreatine concentration decreased from 15.9 ± 3.3 to 2.8 ± 1.0, and the adenosine triphosphate concentration decreased from 6.0 ± 0.5 to 3.5 ± 0.3. Correlated with the diminished concentrations of these compounds was a selective 7 to 25% decrease in the diameter of type II muscle fibers. The presence of extra creatine in the diet prevented at least in part both the decrease in muscle fiber diameter and the biochemical changes. Mice fed β-GPA may serve as a model for the study of the pathogenesis of type II muscle fiber atrophy due to a specific, known biochemical defect." @default.
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- W2034805757 title "Effects of β-guanidinopropionic acid on murine skeletal muscle" @default.
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- W2034805757 doi "https://doi.org/10.1016/0014-4886(80)90070-9" @default.
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