Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034806502> ?p ?o ?g. }
Showing items 1 to 90 of
90
with 100 items per page.
- W2034806502 endingPage "640" @default.
- W2034806502 startingPage "637" @default.
- W2034806502 abstract "Background: The treatment of patients with unresectable liver tumours remains an unsolved clinical problem. Several methods of loco-regional treatment have been developed. These methods rely mainly on direct thermal or chemical insults and consequently have their own inherent limitations in clinical usage. The ‘ideal’ treatment would combine the direct cytotoxic effects of chemical treatments with the relative predictability of thermal insults, without the associated complications. This study aims to investigate whether the direct chemical effect of electrolytic hepatic necrosis is associated with any heating effect, and if so, whether the temperature change is dose–dependent. Methods: An electrolytic ‘dose’ sufficient to induce a localized zone of hepatic necrosis was delivered to the livers of rats and pigs via implanted platinum electrodes. Results: The results showed that there was no significant temperature increase at low current levels (2-4 mA) in the rat liver. In the pig, there was a significant (P < 0.01) increase in temperature of 4.2°C during electrolysis, when delivered at between 20 and 50 mA. However, such a small increase in temperature would have been insufficient to cause appreciable thermal necrosis. Conclusions: This study demonstrates that electrolysis-induced hepatic necrosis is produced without an increase in temperature; clearly cell death results from the direct effects of cytotoxic electrode products and an alteration of intracellular pH. Consequently, it is likely that as a method for ablating liver tumours, electrolysis should be associated with fewer complications than other forms of locoregional treatment." @default.
- W2034806502 created "2016-06-24" @default.
- W2034806502 creator A5040877786 @default.
- W2034806502 creator A5057491430 @default.
- W2034806502 creator A5084365136 @default.
- W2034806502 creator A5086946129 @default.
- W2034806502 date "1998-09-01" @default.
- W2034806502 modified "2023-10-06" @default.
- W2034806502 title "ELECTROCHEMICALLY INDUCED HEPATIC NECROSIS: THE NEXT STEP FORWARD IN PATIENTS WITH UNRESECTABLE LIVER TUMOURS?" @default.
- W2034806502 cites W1964989417 @default.
- W2034806502 cites W1965030998 @default.
- W2034806502 cites W1990575105 @default.
- W2034806502 cites W1998088401 @default.
- W2034806502 cites W2025506758 @default.
- W2034806502 cites W2035794433 @default.
- W2034806502 cites W2046413809 @default.
- W2034806502 cites W2079565017 @default.
- W2034806502 cites W2087608779 @default.
- W2034806502 cites W2089983789 @default.
- W2034806502 cites W2104297510 @default.
- W2034806502 cites W2113541371 @default.
- W2034806502 cites W2174820194 @default.
- W2034806502 cites W2326825527 @default.
- W2034806502 cites W2410973671 @default.
- W2034806502 cites W2492163052 @default.
- W2034806502 cites W71121424 @default.
- W2034806502 doi "https://doi.org/10.1111/j.1445-2197.1998.tb04833.x" @default.
- W2034806502 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9737258" @default.
- W2034806502 hasPublicationYear "1998" @default.
- W2034806502 type Work @default.
- W2034806502 sameAs 2034806502 @default.
- W2034806502 citedByCount "35" @default.
- W2034806502 countsByYear W20348065022012 @default.
- W2034806502 countsByYear W20348065022014 @default.
- W2034806502 countsByYear W20348065022018 @default.
- W2034806502 crossrefType "journal-article" @default.
- W2034806502 hasAuthorship W2034806502A5040877786 @default.
- W2034806502 hasAuthorship W2034806502A5057491430 @default.
- W2034806502 hasAuthorship W2034806502A5084365136 @default.
- W2034806502 hasAuthorship W2034806502A5086946129 @default.
- W2034806502 hasConcept C126322002 @default.
- W2034806502 hasConcept C142724271 @default.
- W2034806502 hasConcept C147789679 @default.
- W2034806502 hasConcept C154317977 @default.
- W2034806502 hasConcept C163127949 @default.
- W2034806502 hasConcept C17525397 @default.
- W2034806502 hasConcept C185592680 @default.
- W2034806502 hasConcept C202751555 @default.
- W2034806502 hasConcept C503630168 @default.
- W2034806502 hasConcept C55493867 @default.
- W2034806502 hasConcept C68801617 @default.
- W2034806502 hasConcept C71924100 @default.
- W2034806502 hasConcept C79879829 @default.
- W2034806502 hasConcept C90924648 @default.
- W2034806502 hasConceptScore W2034806502C126322002 @default.
- W2034806502 hasConceptScore W2034806502C142724271 @default.
- W2034806502 hasConceptScore W2034806502C147789679 @default.
- W2034806502 hasConceptScore W2034806502C154317977 @default.
- W2034806502 hasConceptScore W2034806502C163127949 @default.
- W2034806502 hasConceptScore W2034806502C17525397 @default.
- W2034806502 hasConceptScore W2034806502C185592680 @default.
- W2034806502 hasConceptScore W2034806502C202751555 @default.
- W2034806502 hasConceptScore W2034806502C503630168 @default.
- W2034806502 hasConceptScore W2034806502C55493867 @default.
- W2034806502 hasConceptScore W2034806502C68801617 @default.
- W2034806502 hasConceptScore W2034806502C71924100 @default.
- W2034806502 hasConceptScore W2034806502C79879829 @default.
- W2034806502 hasConceptScore W2034806502C90924648 @default.
- W2034806502 hasIssue "9" @default.
- W2034806502 hasLocation W20348065021 @default.
- W2034806502 hasLocation W20348065022 @default.
- W2034806502 hasOpenAccess W2034806502 @default.
- W2034806502 hasPrimaryLocation W20348065021 @default.
- W2034806502 hasRelatedWork W1566390707 @default.
- W2034806502 hasRelatedWork W1964885378 @default.
- W2034806502 hasRelatedWork W1969544286 @default.
- W2034806502 hasRelatedWork W2060287362 @default.
- W2034806502 hasRelatedWork W2215194409 @default.
- W2034806502 hasRelatedWork W2362022522 @default.
- W2034806502 hasRelatedWork W2375572360 @default.
- W2034806502 hasRelatedWork W2378590575 @default.
- W2034806502 hasRelatedWork W2587431702 @default.
- W2034806502 hasRelatedWork W4200588494 @default.
- W2034806502 hasVolume "68" @default.
- W2034806502 isParatext "false" @default.
- W2034806502 isRetracted "false" @default.
- W2034806502 magId "2034806502" @default.
- W2034806502 workType "article" @default.