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- W2034806507 abstract "The incorporation of [14C]glycine into the subunits of skin collagen was followed in normal and lathyritic rats. Label appears first and at the same rate in the primary subunits, α1 and α2, and later in β1 and β2. This is explained by the fact that β1 and β2 are derived from α1 and α2 by intramolecular crosslinking. In lathyritic animals the formation of β1 and β2 is markedly reduced though the synthesis of collagen proceeds. This defect is evident long before the appearance of the gross symptoms of lathyrism. The results are consistent with the suggestion that the lack of intramolecular crosslinks affects the integrity of connective tissue through a loss of fibril stability resulting in the gross symptoms characteristic of lathyrism." @default.
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- W2034806507 date "1963-01-01" @default.
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- W2034806507 title "The incorporation of [14C]glycine into the subunits of collagens from normal and lathyritic animals" @default.
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