FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034807369> ?p ?o ?g. }

• W2034807369 endingPage "108" @default.
• W2034807369 startingPage "102" @default.
• W2034807369 abstract "The present study examined the role of L-/T-type Ca channels and the interaction between these channels and protein kinase C (PKC) in hypertension. The isolated perfused hydronephrotic rat kidney model was used to visualize directly the renal microvascular effects of L-/T-type Ca channel blockers (nifedipine and mibefradil, respectively). Nifedipine reversed the angiotensin II-induced constriction of afferent, but not efferent, arterioles in kidneys from Wistar-Kyoto rats (WKY), and similar magnitude in dilation was observed in spontaneously hypertensive rats (SHR). Although mibefradil elicited dilation of both arterioles, the afferent arteriolar dilation was less in SHR than in WKY (57 ± 5% vs. 80 ± 4% reversal at 1 μmol/L). The pretreatment with staurosporine did not alter the angiotensin II-induced afferent arteriolar constriction in WKY, but attenuated this response in SHR. Furthermore, staurosporine enhanced the nifedipine-induced afferent arteriolar dilation (62 ± 3% vs. 50 ± 3% reversal at 10 μmol/L), and restored the attenuated afferent arteriolar response to mibefradil in SHR. The pretreatment with thapsigargin (a blocker of IP3-mediated intracellular calcium release) prevented the angiotensin II-induced afferent arteriolar constriction in WKY, but caused a significant constriction of afferent arterioles in SHR and efferent arterioles in WKY and SHR; in this setting, mibefradil did not alter efferent arteriolar tone. In conclusion, although both L-type (nifedipine) and T-type Ca channel blockers (mibefradil) exerted potent vasodilation of rat renal microvessels, these actions were modified by PKC, which determined the afferent arteriolar sensitivity to these blockers in SHR. Furthermore, the enhancement in nifedipine-induced afferent arteriolar dilation by staurosporine in SHR suggests that L-type Ca channel activity is augmented in hypertensive animals." @default.
• W2034807369 created "2016-06-24" @default.
• W2034807369 creator A5001299618 @default.
• W2034807369 creator A5003412793 @default.
• W2034807369 creator A5004071991 @default.
• W2034807369 creator A5015476095 @default.
• W2034807369 creator A5032392003 @default.
• W2034807369 creator A5036863557 @default.
• W2034807369 creator A5042975050 @default.
• W2034807369 creator A5070233410 @default.
• W2034807369 creator A5071950136 @default.
• W2034807369 creator A5089373241 @default.
• W2034807369 date "2005-01-01" @default.
• W2034807369 modified "2023-10-05" @default.
• W2034807369 title "Role of protein kinase C in Ca channel blocker-induced renal arteriolar dilation in spontaneously hypertensive rats" @default.
• W2034807369 cites W1597787921 @default.
• W2034807369 cites W1788013840 @default.
• W2034807369 cites W1965946150 @default.
• W2034807369 cites W1967026909 @default.
• W2034807369 cites W1972441590 @default.
• W2034807369 cites W1979328703 @default.
• W2034807369 cites W1984570694 @default.
• W2034807369 cites W1991663653 @default.
• W2034807369 cites W2003410167 @default.
• W2034807369 cites W2014933196 @default.
• W2034807369 cites W2018059911 @default.
• W2034807369 cites W2018201944 @default.
• W2034807369 cites W2029031494 @default.
• W2034807369 cites W2033335308 @default.
• W2034807369 cites W2034877370 @default.
• W2034807369 cites W2037866615 @default.
• W2034807369 cites W2038724320 @default.
• W2034807369 cites W2041807576 @default.
• W2034807369 cites W2043736479 @default.
• W2034807369 cites W2048540724 @default.
• W2034807369 cites W2059267207 @default.
• W2034807369 cites W2063186210 @default.
• W2034807369 cites W2063535351 @default.
• W2034807369 cites W2066335466 @default.
• W2034807369 cites W2093705854 @default.
• W2034807369 cites W2096816041 @default.
• W2034807369 cites W2102204826 @default.
• W2034807369 cites W2116200265 @default.
• W2034807369 cites W2138443098 @default.
• W2034807369 cites W2144451075 @default.
• W2034807369 cites W2146597863 @default.
• W2034807369 cites W2148942684 @default.
• W2034807369 cites W2149466776 @default.
• W2034807369 cites W2157086523 @default.
• W2034807369 cites W2171830917 @default.
• W2034807369 cites W2185806249 @default.
• W2034807369 cites W2188042985 @default.
• W2034807369 cites W2414454710 @default.
• W2034807369 cites W333268629 @default.
• W2034807369 cites W2340954606 @default.
• W2034807369 doi "https://doi.org/10.2302/kjm.54.102" @default.
• W2034807369 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16077260" @default.
• W2034807369 hasPublicationYear "2005" @default.
• W2034807369 type Work @default.
• W2034807369 sameAs 2034807369 @default.
• W2034807369 citedByCount "4" @default.
• W2034807369 countsByYear W20348073692015 @default.
• W2034807369 crossrefType "journal-article" @default.
• W2034807369 hasAuthorship W2034807369A5001299618 @default.
• W2034807369 hasAuthorship W2034807369A5003412793 @default.
• W2034807369 hasAuthorship W2034807369A5004071991 @default.
• W2034807369 hasAuthorship W2034807369A5015476095 @default.
• W2034807369 hasAuthorship W2034807369A5032392003 @default.
• W2034807369 hasAuthorship W2034807369A5036863557 @default.
• W2034807369 hasAuthorship W2034807369A5042975050 @default.
• W2034807369 hasAuthorship W2034807369A5070233410 @default.
• W2034807369 hasAuthorship W2034807369A5071950136 @default.
• W2034807369 hasAuthorship W2034807369A5089373241 @default.
• W2034807369 hasBestOaLocation W20348073691 @default.
• W2034807369 hasConcept C126322002 @default.
• W2034807369 hasConcept C134018914 @default.
• W2034807369 hasConcept C153461711 @default.
• W2034807369 hasConcept C170493617 @default.
• W2034807369 hasConcept C185592680 @default.
• W2034807369 hasConcept C2776512019 @default.
• W2034807369 hasConcept C2778673320 @default.
• W2034807369 hasConcept C2779066535 @default.
• W2034807369 hasConcept C2779263132 @default.
• W2034807369 hasConcept C2780356492 @default.
• W2034807369 hasConcept C2780636983 @default.
• W2034807369 hasConcept C2908929049 @default.
• W2034807369 hasConcept C519063684 @default.
• W2034807369 hasConcept C71924100 @default.
• W2034807369 hasConcept C85520022 @default.
• W2034807369 hasConceptScore W2034807369C126322002 @default.
• W2034807369 hasConceptScore W2034807369C134018914 @default.
• W2034807369 hasConceptScore W2034807369C153461711 @default.
• W2034807369 hasConceptScore W2034807369C170493617 @default.
• W2034807369 hasConceptScore W2034807369C185592680 @default.
• W2034807369 hasConceptScore W2034807369C2776512019 @default.
• W2034807369 hasConceptScore W2034807369C2778673320 @default.
• W2034807369 hasConceptScore W2034807369C2779066535 @default.
• W2034807369 hasConceptScore W2034807369C2779263132 @default.

• next