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• W2034808502 endingPage "H2732" @default.
• W2034808502 startingPage "H2725" @default.
• W2034808502 abstract "We developed an in situ assay system to simultaneously monitor intracellular Ca(2+) concentration ([Ca(2+)](i), fura 2 as indicator) and nitric oxide (NO) levels [4,5-diaminofluorescein as probe] in the intact endothelium of small bovine coronary arteries by using a fluorescent microscopic imaging technique with high-speed wavelength switching. Bradykinin (BK; 1 microM) stimulated a rapid increase in [Ca(2+)](i) followed by an increase in NO production in the endothelial cells. The protein tyrosine phosphatase inhibitor phenylarsine oxide (PAO; 10 microM) induced a gradual, small increase in [Ca(2+)](i) and a slow increase in intracellular NO levels. Removal of extracellular Ca(2+) and depletion of Ca(2+) stores completely blocked BK-induced increase in NO production but had no effect on PAO-induced NO production. However, a further reduction of [Ca(2+)](i) by application of BAPTA-AM or EGTA with ionomycin abolished the PAO-induced NO increase. These results indicate that a simultaneous monitoring of [Ca(2+)](i) and intracellular NO production in the intact endothelium is a powerful tool to study Ca(2+)-dependent regulation of endothelial nitric oxide synthase, which provides the first direct evidence for a permissive role of Ca(2+) in tyrosine phosphorylation-induced NO production." @default.
• W2034808502 created "2016-06-24" @default.
• W2034808502 creator A5003769038 @default.
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• W2034808502 date "2002-12-01" @default.
• W2034808502 modified "2023-10-18" @default.
• W2034808502 title "Simultaneous in situ monitoring of intracellular Ca²⁺and NO in endothelium of coronary arteries" @default.
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• W2034808502 doi "https://doi.org/10.1152/ajpheart.00428.2002" @default.
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