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• W2034808734 abstract "The in vitro effects of dexamethasone (Dx) and low and high-dose 6-methylprednisolone (MP) on the expression of adhesion molecules ICAM-1, VCAM-1 and class II antigen HLA-DR on human brain endothelial cells (HBECs) was studied. HBECs were obtained from the surgical specimen of a multiple sclerosis patient undergoing brain surgery for vascular aneurysm. HBECs obtained from apparently normal brain capillaries of surgical specimens of two patients undergoing brain surgery for a meningioma and a low-grade glioma, respectively, were used as controls. The effect of steroids was studied both in the basal condition and after stimulation with proinflammatory cytokines (γ-IFN and TNF-α). In order to detect possible endothelium local tissue specific differences, the experiment was repeated using human umbilical vein endothelial cells (HUVECs). Only high-dose MP was able to down-regulate TNF-α-induced VCAM-1 expression on endothelial cells." @default.
• W2034808734 created "2016-06-24" @default.
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• W2034808734 date "1998-05-01" @default.
• W2034808734 modified "2023-09-26" @default.
• W2034808734 title "Modulation of ICAM-1, VCAM-1 and HLA-DR by cytokines and steroids on HUVECs and human brain endothelial cells" @default.
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• W2034808734 doi "https://doi.org/10.1016/s0022-510x(98)00059-8" @default.
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