Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034809921> ?p ?o ?g. }
Showing items 1 to 95 of
95
with 100 items per page.
- W2034809921 endingPage "852" @default.
- W2034809921 startingPage "847" @default.
- W2034809921 abstract "Rac1, a member of the Rho subfamily of small GTPases, is involved in morphogenesis and differentiation of many cell types. Here we define a role of Rac1 in cardiac development by specifically deleting Rac1 in the pre-cardiac mesoderm using the Nkx2.5-Cre transgenic driver line. Rac1-conditional knockout embryos initiate heart development normally until embryonic day 11.5 (E11.5); their cardiac mesoderm is specified, and the heart tube is formed and looped. However, by E12.5-E13.5 the mutant hearts start failing and embryos develop edema and hemorrhage which is probably the cause for the lethality observed soon after. The hearts of Rac1-cKO embryos exhibit disorganized and thin myocardial walls and defects in outflow tract alignment. No significant differences of cardiomyocyte death or proliferation were found between developing control and mutant embryos. To uncover the role of Rac1 in the heart, E11.5 primary heart cells were cultured and analyzed in vitro. Rac1-deficient cardiomyocytes were less spread, round and loosely attached to the substrate and to each other implying that Rac1-mediated signaling is required for appropriate cell–cell and/or cellmatrix adhesion during cardiac development." @default.
- W2034809921 created "2016-06-24" @default.
- W2034809921 creator A5090671586 @default.
- W2034809921 date "2015-01-01" @default.
- W2034809921 modified "2023-09-25" @default.
- W2034809921 title "Rac1 modulates cardiomyocyte adhesion during mouse embryonic development" @default.
- W2034809921 cites W1520697307 @default.
- W2034809921 cites W1768274470 @default.
- W2034809921 cites W1948361600 @default.
- W2034809921 cites W1975829169 @default.
- W2034809921 cites W1986810405 @default.
- W2034809921 cites W1987509690 @default.
- W2034809921 cites W1991592847 @default.
- W2034809921 cites W1994567959 @default.
- W2034809921 cites W2003145436 @default.
- W2034809921 cites W2006685944 @default.
- W2034809921 cites W2022211910 @default.
- W2034809921 cites W2032224996 @default.
- W2034809921 cites W2036517975 @default.
- W2034809921 cites W2046365944 @default.
- W2034809921 cites W2054913890 @default.
- W2034809921 cites W2061482218 @default.
- W2034809921 cites W2065456701 @default.
- W2034809921 cites W2082427792 @default.
- W2034809921 cites W2089472706 @default.
- W2034809921 cites W2093229168 @default.
- W2034809921 cites W2093797379 @default.
- W2034809921 cites W2109747579 @default.
- W2034809921 cites W2116432506 @default.
- W2034809921 cites W2127312743 @default.
- W2034809921 cites W2132983780 @default.
- W2034809921 cites W2149290707 @default.
- W2034809921 cites W2151103961 @default.
- W2034809921 doi "https://doi.org/10.1016/j.bbrc.2014.12.042" @default.
- W2034809921 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25514037" @default.
- W2034809921 hasPublicationYear "2015" @default.
- W2034809921 type Work @default.
- W2034809921 sameAs 2034809921 @default.
- W2034809921 citedByCount "4" @default.
- W2034809921 countsByYear W20348099212018 @default.
- W2034809921 countsByYear W20348099212019 @default.
- W2034809921 countsByYear W20348099212020 @default.
- W2034809921 countsByYear W20348099212023 @default.
- W2034809921 crossrefType "journal-article" @default.
- W2034809921 hasAuthorship W2034809921A5090671586 @default.
- W2034809921 hasConcept C102230213 @default.
- W2034809921 hasConcept C104317684 @default.
- W2034809921 hasConcept C141035611 @default.
- W2034809921 hasConcept C145103041 @default.
- W2034809921 hasConcept C196843134 @default.
- W2034809921 hasConcept C2777164004 @default.
- W2034809921 hasConcept C2779717556 @default.
- W2034809921 hasConcept C2780915607 @default.
- W2034809921 hasConcept C40692019 @default.
- W2034809921 hasConcept C54355233 @default.
- W2034809921 hasConcept C62425271 @default.
- W2034809921 hasConcept C62478195 @default.
- W2034809921 hasConcept C86803240 @default.
- W2034809921 hasConcept C95444343 @default.
- W2034809921 hasConceptScore W2034809921C102230213 @default.
- W2034809921 hasConceptScore W2034809921C104317684 @default.
- W2034809921 hasConceptScore W2034809921C141035611 @default.
- W2034809921 hasConceptScore W2034809921C145103041 @default.
- W2034809921 hasConceptScore W2034809921C196843134 @default.
- W2034809921 hasConceptScore W2034809921C2777164004 @default.
- W2034809921 hasConceptScore W2034809921C2779717556 @default.
- W2034809921 hasConceptScore W2034809921C2780915607 @default.
- W2034809921 hasConceptScore W2034809921C40692019 @default.
- W2034809921 hasConceptScore W2034809921C54355233 @default.
- W2034809921 hasConceptScore W2034809921C62425271 @default.
- W2034809921 hasConceptScore W2034809921C62478195 @default.
- W2034809921 hasConceptScore W2034809921C86803240 @default.
- W2034809921 hasConceptScore W2034809921C95444343 @default.
- W2034809921 hasIssue "4" @default.
- W2034809921 hasLocation W20348099211 @default.
- W2034809921 hasLocation W20348099212 @default.
- W2034809921 hasOpenAccess W2034809921 @default.
- W2034809921 hasPrimaryLocation W20348099211 @default.
- W2034809921 hasRelatedWork W1979145849 @default.
- W2034809921 hasRelatedWork W1983650879 @default.
- W2034809921 hasRelatedWork W2048505114 @default.
- W2034809921 hasRelatedWork W2085367169 @default.
- W2034809921 hasRelatedWork W2094651478 @default.
- W2034809921 hasRelatedWork W2098049105 @default.
- W2034809921 hasRelatedWork W2109484572 @default.
- W2034809921 hasRelatedWork W2133460513 @default.
- W2034809921 hasRelatedWork W2741887047 @default.
- W2034809921 hasRelatedWork W2950085814 @default.
- W2034809921 hasVolume "456" @default.
- W2034809921 isParatext "false" @default.
- W2034809921 isRetracted "false" @default.
- W2034809921 magId "2034809921" @default.
- W2034809921 workType "article" @default.