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- W2034811298 abstract "Careful selection and treatment monitoring of patients with gestational trophoblastic tumors (GTT) is critical because 20–50% of patients may develop a resistance and consequently require alternative chemotherapeutic agents. In our study we propose and demonstrate the efficacy of etoposide (VP16) as a second-line drug. An average of 5 courses with VP16 were used to achieve a remission in 12 patients resistant to MTX with low-risk GTT. Toxicity was mild and no resistance to VP16 was observed. A follow-up of 66 months (range, 22–109) has been performed for the patients and all of them are now disease free. Two patients had a pregnancy, respectively, 3 and 4 years after treatment. The others did not desire any pregnancy." @default.
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- W2034811298 date "1996-05-01" @default.
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- W2034811298 title "Management of Low-Risk Gestational Trophoblastic Tumors with Etoposide (VP16) in Patients Resistant to Methotrexate" @default.
- W2034811298 doi "https://doi.org/10.1006/gyno.1996.0128" @default.
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