Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034814721> ?p ?o ?g. }
- W2034814721 endingPage "192" @default.
- W2034814721 startingPage "186" @default.
- W2034814721 abstract "After renal transplantation immunosuppressive drugs-like cyclosporin A (CsA) and FK506 induce either hypoaldosteronism or pseudo-hypoaldosteronism presenting with hyperkalemia and metabolic acidosis. We investigated the relationship between renal allograft function under CsA therapy and plasma aldosterone concentration, potassium- and water homeostasis and mineralocorticoid receptor (MR) expression level in peripheral leukocytes.We studied 21 renal transplant patients under CsA therapy and 12 healthy controls. Transplant recipients were studied before and under fludrocortisone treatment. Using quantitative reverse-phase polymerase chain reaction (RT-PCR) specific for the MR, we analyzed the level of expression of MR in peripheral leukocytes.In acidotic transplant recipients (HCO(3) 18.5 +/- 1.2 mM) renal function was only slightly impaired with 2.0 +/- 0.2 mg creatinine/dL when compared with 1.8 +/- 0.3 mg/dL (ns) in non-acidotic patients (HCO(3) 23.0 +/- 2.8 mM). Mean plasma aldosterone levels in renal transplant recipients did not differ from control levels (150 +/- 33 pg/mL vs. 148 +/- 33 pg/mL, ns). In contrast, the expression level of MR in peripheral leukocytes of renal transplant recipients treated with CsA was significantly decreased when compared with healthy controls without renal disease (120 +/- 78 vs. 423 +/- 73 RNA molecules/0.5 microg total RNA, p < 0.01). The level of expression of MR in renal transplant recipients did not differ between acidotic patients and non-acidotic patients (ns). The application of fludrocortisone reversed hyperkalemia and metabolic acidosis without significant effect on MR expression.The present data demonstrate that hyperkalemia and metabolic acidosis following CsA treatment in kidney transplantation might be associated with a down-regulation of MR expression on peripheral leukocytes. Electrolyte imbalance is reversible on application of fludrocortisone. This observation supports fludrocortisone treatment in transplant patients with severe electrolyte disturbances." @default.
- W2034814721 created "2016-06-24" @default.
- W2034814721 creator A5007962744 @default.
- W2034814721 creator A5034456564 @default.
- W2034814721 creator A5074589045 @default.
- W2034814721 creator A5078927052 @default.
- W2034814721 creator A5082690120 @default.
- W2034814721 creator A5090796057 @default.
- W2034814721 date "2004-03-08" @default.
- W2034814721 modified "2023-10-17" @default.
- W2034814721 title "Aldosterone resistance in kidney transplantation is in part induced by a down-regulation of mineralocorticoid receptor expression1" @default.
- W2034814721 cites W1749258448 @default.
- W2034814721 cites W1967322127 @default.
- W2034814721 cites W2008652640 @default.
- W2034814721 cites W2026911087 @default.
- W2034814721 cites W2029473664 @default.
- W2034814721 cites W2035856471 @default.
- W2034814721 cites W2043701606 @default.
- W2034814721 cites W2048813075 @default.
- W2034814721 cites W2060016825 @default.
- W2034814721 cites W2063231321 @default.
- W2034814721 cites W2089502199 @default.
- W2034814721 cites W2096563677 @default.
- W2034814721 cites W2325005910 @default.
- W2034814721 cites W4239146840 @default.
- W2034814721 cites W4244646777 @default.
- W2034814721 cites W4248992638 @default.
- W2034814721 cites W4254336299 @default.
- W2034814721 doi "https://doi.org/10.1046/j.1399-0012.2003.00154.x" @default.
- W2034814721 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15016134" @default.
- W2034814721 hasPublicationYear "2004" @default.
- W2034814721 type Work @default.
- W2034814721 sameAs 2034814721 @default.
- W2034814721 citedByCount "37" @default.
- W2034814721 countsByYear W20348147212012 @default.
- W2034814721 countsByYear W20348147212014 @default.
- W2034814721 countsByYear W20348147212015 @default.
- W2034814721 countsByYear W20348147212016 @default.
- W2034814721 countsByYear W20348147212017 @default.
- W2034814721 countsByYear W20348147212018 @default.
- W2034814721 countsByYear W20348147212019 @default.
- W2034814721 countsByYear W20348147212020 @default.
- W2034814721 countsByYear W20348147212021 @default.
- W2034814721 countsByYear W20348147212022 @default.
- W2034814721 countsByYear W20348147212023 @default.
- W2034814721 crossrefType "journal-article" @default.
- W2034814721 hasAuthorship W2034814721A5007962744 @default.
- W2034814721 hasAuthorship W2034814721A5034456564 @default.
- W2034814721 hasAuthorship W2034814721A5074589045 @default.
- W2034814721 hasAuthorship W2034814721A5078927052 @default.
- W2034814721 hasAuthorship W2034814721A5082690120 @default.
- W2034814721 hasAuthorship W2034814721A5090796057 @default.
- W2034814721 hasConcept C126322002 @default.
- W2034814721 hasConcept C126894567 @default.
- W2034814721 hasConcept C134018914 @default.
- W2034814721 hasConcept C159641895 @default.
- W2034814721 hasConcept C189135053 @default.
- W2034814721 hasConcept C198710026 @default.
- W2034814721 hasConcept C2776069600 @default.
- W2034814721 hasConcept C2776138174 @default.
- W2034814721 hasConcept C2776899810 @default.
- W2034814721 hasConcept C2778525890 @default.
- W2034814721 hasConcept C2778553927 @default.
- W2034814721 hasConcept C2778653478 @default.
- W2034814721 hasConcept C2778709874 @default.
- W2034814721 hasConcept C2779246250 @default.
- W2034814721 hasConcept C2780243291 @default.
- W2034814721 hasConcept C2780303639 @default.
- W2034814721 hasConcept C2780306776 @default.
- W2034814721 hasConcept C2911091166 @default.
- W2034814721 hasConcept C71924100 @default.
- W2034814721 hasConcept C84393581 @default.
- W2034814721 hasConceptScore W2034814721C126322002 @default.
- W2034814721 hasConceptScore W2034814721C126894567 @default.
- W2034814721 hasConceptScore W2034814721C134018914 @default.
- W2034814721 hasConceptScore W2034814721C159641895 @default.
- W2034814721 hasConceptScore W2034814721C189135053 @default.
- W2034814721 hasConceptScore W2034814721C198710026 @default.
- W2034814721 hasConceptScore W2034814721C2776069600 @default.
- W2034814721 hasConceptScore W2034814721C2776138174 @default.
- W2034814721 hasConceptScore W2034814721C2776899810 @default.
- W2034814721 hasConceptScore W2034814721C2778525890 @default.
- W2034814721 hasConceptScore W2034814721C2778553927 @default.
- W2034814721 hasConceptScore W2034814721C2778653478 @default.
- W2034814721 hasConceptScore W2034814721C2778709874 @default.
- W2034814721 hasConceptScore W2034814721C2779246250 @default.
- W2034814721 hasConceptScore W2034814721C2780243291 @default.
- W2034814721 hasConceptScore W2034814721C2780303639 @default.
- W2034814721 hasConceptScore W2034814721C2780306776 @default.
- W2034814721 hasConceptScore W2034814721C2911091166 @default.
- W2034814721 hasConceptScore W2034814721C71924100 @default.
- W2034814721 hasConceptScore W2034814721C84393581 @default.
- W2034814721 hasIssue "2" @default.
- W2034814721 hasLocation W20348147211 @default.
- W2034814721 hasLocation W20348147212 @default.
- W2034814721 hasOpenAccess W2034814721 @default.
- W2034814721 hasPrimaryLocation W20348147211 @default.
- W2034814721 hasRelatedWork W187973100 @default.