Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034817767> ?p ?o ?g. }
- W2034817767 endingPage "205" @default.
- W2034817767 startingPage "200" @default.
- W2034817767 abstract "Chronic myeloproliferative diseases (CMPDs) are characterized by the abnormal proliferation and survival of one or more myeloid cell types. The archetype of this class of hematological diseases is chronic myeloid leukemia (CML), characterized by the presence of the Philadelphia (Ph) chromosome, the result of t(9;22)(q34;q11), and the associated BCR-ABL1 oncogene. Some of the Ph-negative myeloproliferative diseases are characterized by other chromosomal translocations involving a variety of tyrosine kinase genes, including ABL1, ABL2, PDGFRA, PDGFRB, FGFR1, and JAK2. The majority of Ph-negative CMPDs, however, such as chronic eosinophilic leukemia, polycythemia vera, essential thrombocythemia, and idiopathic myelofibrosis are not characterized by the presence of recurrent chromosomal abnormalities. Recent studies have identified the FIP1L1-PDGFRA fusion gene, generated due to a small cryptic deletion on chromosome 4q12, and the activating V617F mutation in JAK2 in a significant fraction of Ph-negative CMPDs. These results show that abnormalities in tyrosine kinase genes are central to the molecular pathogenesis of CMPDs. Genome-wide screenings to identify novel tyrosine kinase abnormalities in CMPDs may contribute to further improvement of the diagnosis and the treatment of these diseases." @default.
- W2034817767 created "2016-06-24" @default.
- W2034817767 creator A5060184481 @default.
- W2034817767 creator A5077602004 @default.
- W2034817767 date "2005-12-08" @default.
- W2034817767 modified "2023-10-12" @default.
- W2034817767 title "Chronic myeloproliferative disorders: a tyrosine kinase tale" @default.
- W2034817767 cites W11727989 @default.
- W2034817767 cites W1571014830 @default.
- W2034817767 cites W1575487317 @default.
- W2034817767 cites W1972112588 @default.
- W2034817767 cites W1977394892 @default.
- W2034817767 cites W1980568348 @default.
- W2034817767 cites W1998079029 @default.
- W2034817767 cites W1999608888 @default.
- W2034817767 cites W2000893535 @default.
- W2034817767 cites W2001426718 @default.
- W2034817767 cites W2001737705 @default.
- W2034817767 cites W2002209196 @default.
- W2034817767 cites W2012828386 @default.
- W2034817767 cites W2012952884 @default.
- W2034817767 cites W2014149238 @default.
- W2034817767 cites W2016276643 @default.
- W2034817767 cites W2016396075 @default.
- W2034817767 cites W2019186253 @default.
- W2034817767 cites W2019952415 @default.
- W2034817767 cites W2023217887 @default.
- W2034817767 cites W2025645148 @default.
- W2034817767 cites W2027684265 @default.
- W2034817767 cites W2027973770 @default.
- W2034817767 cites W2036180570 @default.
- W2034817767 cites W2042011247 @default.
- W2034817767 cites W2048993739 @default.
- W2034817767 cites W2049145190 @default.
- W2034817767 cites W2049447930 @default.
- W2034817767 cites W2049449785 @default.
- W2034817767 cites W2053846867 @default.
- W2034817767 cites W2057360098 @default.
- W2034817767 cites W2064244980 @default.
- W2034817767 cites W2064698668 @default.
- W2034817767 cites W2065112197 @default.
- W2034817767 cites W2066913808 @default.
- W2034817767 cites W2069578188 @default.
- W2034817767 cites W2075428599 @default.
- W2034817767 cites W2077187679 @default.
- W2034817767 cites W2085573901 @default.
- W2034817767 cites W2088175344 @default.
- W2034817767 cites W2092606584 @default.
- W2034817767 cites W2101502003 @default.
- W2034817767 cites W2105949419 @default.
- W2034817767 cites W2112849051 @default.
- W2034817767 cites W2116768113 @default.
- W2034817767 cites W2118072401 @default.
- W2034817767 cites W2118240561 @default.
- W2034817767 cites W2124196948 @default.
- W2034817767 cites W2126665281 @default.
- W2034817767 cites W2129398278 @default.
- W2034817767 cites W2134085362 @default.
- W2034817767 cites W2138165161 @default.
- W2034817767 cites W2141324982 @default.
- W2034817767 cites W2141949848 @default.
- W2034817767 cites W2142161829 @default.
- W2034817767 cites W2144198294 @default.
- W2034817767 cites W2144997552 @default.
- W2034817767 cites W2150953357 @default.
- W2034817767 cites W2153697948 @default.
- W2034817767 cites W2162525969 @default.
- W2034817767 cites W2163876274 @default.
- W2034817767 cites W2329648702 @default.
- W2034817767 cites W32931231 @default.
- W2034817767 cites W39467412 @default.
- W2034817767 cites W4237200993 @default.
- W2034817767 cites W4255161169 @default.
- W2034817767 doi "https://doi.org/10.1038/sj.leu.2404064" @default.
- W2034817767 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16341034" @default.
- W2034817767 hasPublicationYear "2005" @default.
- W2034817767 type Work @default.
- W2034817767 sameAs 2034817767 @default.
- W2034817767 citedByCount "71" @default.
- W2034817767 countsByYear W20348177672012 @default.
- W2034817767 countsByYear W20348177672013 @default.
- W2034817767 countsByYear W20348177672014 @default.
- W2034817767 countsByYear W20348177672015 @default.
- W2034817767 countsByYear W20348177672016 @default.
- W2034817767 countsByYear W20348177672018 @default.
- W2034817767 countsByYear W20348177672019 @default.
- W2034817767 countsByYear W20348177672021 @default.
- W2034817767 crossrefType "journal-article" @default.
- W2034817767 hasAuthorship W2034817767A5060184481 @default.
- W2034817767 hasAuthorship W2034817767A5077602004 @default.
- W2034817767 hasBestOaLocation W20348177671 @default.
- W2034817767 hasConcept C104317684 @default.
- W2034817767 hasConcept C111829193 @default.
- W2034817767 hasConcept C125418893 @default.
- W2034817767 hasConcept C138626823 @default.
- W2034817767 hasConcept C16930146 @default.
- W2034817767 hasConcept C203014093 @default.
- W2034817767 hasConcept C2775922572 @default.