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- W2034825301 abstract "Heterogeneous and dynamic single cell migration behaviours arise from a complex multi-scale signalling network comprising both molecular components and macromolecular modules, among which cell-matrix adhesions and F-actin directly mediate migration. To date, the global wiring architecture characterizing this network remains poorly defined. It is also unclear whether such a wiring pattern may be stable and generalizable to different conditions, or plastic and context dependent. Here, synchronous imaging-based quantification of migration system organization, represented by 87 morphological and dynamic macromolecular module features, and migration system behaviour, i.e., migration speed, facilitated Granger causality analysis. We thereby leveraged natural cellular heterogeneity to begin mapping the directionally specific causal wiring between organizational and behavioural features of the cell migration system. This represents an important advance on commonly used correlative analyses that do not resolve causal directionality. We identified organizational features such as adhesion stability and adhesion F-actin content that, as anticipated, causally influenced cell migration speed. Strikingly, we also found that cell speed can exert causal influence over organizational features, including cell shape and adhesion complex location, thus revealing causality in directions contradictory to previous expectations. Importantly, by comparing unperturbed and signalling-modulated cells, we provide proof-of-principle that causal interaction patterns are in fact plastic and context dependent, rather than stable and generalizable." @default.
- W2034825301 created "2016-06-24" @default.
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- W2034825301 date "2014-02-28" @default.
- W2034825301 modified "2023-10-16" @default.
- W2034825301 title "Plasticity in the Macromolecular-Scale Causal Networks of Cell Migration" @default.
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- W2034825301 cites W1969430572 @default.
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- W2034825301 cites W1986120913 @default.
- W2034825301 cites W1988194926 @default.
- W2034825301 cites W1990723931 @default.
- W2034825301 cites W1996583422 @default.
- W2034825301 cites W2004208717 @default.
- W2034825301 cites W2007250557 @default.
- W2034825301 cites W2007660746 @default.
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- W2034825301 cites W2018045523 @default.
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- W2034825301 doi "https://doi.org/10.1371/journal.pone.0090593" @default.
- W2034825301 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3938764" @default.
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