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- W2034826045 abstract "Significance Bone anabolic stimuli activate canonical Wnt/β-catenin signaling and human mutations of this pathway underscore its essential role in bone accrual. However, the cell responsible for orchestrating these actions has remained elusive. This study identifies osteocytes as mediators of the anabolic effect of canonical Wnt/β-catenin signaling in bone; further, it dissects desired (bone gain) from undesired (decreased resorption and leukemia) outcomes by selective activation of canonical Wnt/β-catenin signaling in osteocytes versus osteoblasts. Long-lived osteocytes constitute more than 90% of bone cells, thus representing more logical and effective target cells to induce bone anabolism than scarce, short-lived osteoblasts. These findings pave the way toward the development of better treatments for osteoporosis and other bone-related disorders targeting osteocytic Wnt/β-catenin signaling." @default.
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- W2034826045 date "2015-01-20" @default.
- W2034826045 modified "2023-10-14" @default.
- W2034826045 title "Osteocytes mediate the anabolic actions of canonical Wnt/β-catenin signaling in bone" @default.
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- W2034826045 doi "https://doi.org/10.1073/pnas.1409857112" @default.
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