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- W2034831606 abstract "The fate of epidermal growth factor (EGF) after internalization by A431 cells was studied. First, cells containing 125 I‐EGF‐receptor complexes in endosomes were obtained. Subsequent incubation of the cells at 37°C resulted in the recycling of 125 I‐EGF from endosomes to the cell surface in the receptor‐bound state and the gradual release of recycled ligand into the medium. The excess of unlabeled EGF blocked both rebinding and re‐internalization of recycled 125 I‐EGF to produce enhanced accumulation of ligand in the medium. The rate of recycling was shown to be much higher than that of EGF degradation." @default.
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- W2034831606 date "1987-08-31" @default.
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- W2034831606 title "Recycling of epidermal growth factor in A431 cells" @default.
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- W2034831606 doi "https://doi.org/10.1016/0014-5793(87)80361-7" @default.
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