Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034831859> ?p ?o ?g. }
- W2034831859 endingPage "342" @default.
- W2034831859 startingPage "327" @default.
- W2034831859 abstract "Experiments were conducted to determine the role of the aryl hydrocarbon receptor (AhR) in the development of control and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-exposed C57Bl/6 male mice. Male and female mice heterozygous for the AhR (Ahr +/-) were mated, and pregnant females were dosed orally on gestation day 13 with corn oil vehicle or TCDD (5 µg/kg). Pups were necropsied on postnatal day (PND) 21, 35, and 90. Comparison of vehicle-exposed wild-type (Ahr +/+) pups with vehicle-exposed AhR knockout (AhRKO; Ahr -/-) pups confirmed and extended previous reports that development of the liver, heart, spleen, thymus, and kidney is affected by absence of the AhR. Lung, submandibular gland, testis, and epididymis weights were also affected, indicating that the AhR plays a role in normal development of these organs as well. The presence or absence of the AhR had no effect on the incidence of hydronephrosis, daily sperm production, or cauda epididymal sperm numbers in vehicle-exposed mice. TCDD caused numerous effects in wild-type mice that were absent in AhRKO mice; specifically, hydronephrosis, increases in relative liver and heart weight, decreases in absolute heart and lung weight, and decreases in absolute and relative thymus, submandibular gland, epididymis, and testis weight. In several cases, TCDD produced one effect in wild-type mice (reductions in body weight and absolute thymus, submandibular gland, and epididymis weight on PND 21; and reductions in absolute and relative submandibular gland and absolute testis weight on PND 35) but caused the opposite effect in AhRKO mice. In yet other cases (reduced relative spleen weight on PND 21 and reductions in absolute and relative thymus weight on PND 35), TCDD produced similar effects in wild-type and AhRKO mice. There were also cases in which TCDD significantly affected AhRKO mice without significantly altering the same endpoint in wild-type mice; absolute liver, lung, and kidney weight were increased and relative submandibular gland weight was decreased on PND 21; relative heart weight was reduced and absolute lung weight increased on PND 35; and relative liver weight was decreased on PND 90. Although many effects of TCDD required the presence of the AhR, these results provide evidence either for multiple forms of the AhR in mice (one or more of which are still present in AhRKO mice), or for AhR-independent effects of low-level TCDD exposure." @default.
- W2034831859 created "2016-06-24" @default.
- W2034831859 creator A5017259921 @default.
- W2034831859 creator A5025927483 @default.
- W2034831859 creator A5031750107 @default.
- W2034831859 creator A5056294730 @default.
- W2034831859 creator A5067831607 @default.
- W2034831859 creator A5084079702 @default.
- W2034831859 date "2001-10-26" @default.
- W2034831859 modified "2023-09-27" @default.
- W2034831859 title "ROLE OF THE ARYL HYDROCARBON RECEPTOR IN THE DEVELOPMENT OF CONTROL AND 2,3,7,8-TETRACHLORODIBENZO-<i>p</i>-DIOXIN-EXPOSED MALE MICE" @default.
- W2034831859 cites W1937346665 @default.
- W2034831859 cites W1988333201 @default.
- W2034831859 cites W1997013077 @default.
- W2034831859 cites W2014683687 @default.
- W2034831859 cites W2031765358 @default.
- W2034831859 cites W2045054061 @default.
- W2034831859 cites W2051936021 @default.
- W2034831859 cites W2059565720 @default.
- W2034831859 cites W2090939833 @default.
- W2034831859 cites W2091726431 @default.
- W2034831859 cites W2098199658 @default.
- W2034831859 cites W2105262817 @default.
- W2034831859 cites W2108625184 @default.
- W2034831859 cites W2122309505 @default.
- W2034831859 cites W2124739658 @default.
- W2034831859 cites W2159219345 @default.
- W2034831859 cites W2160811937 @default.
- W2034831859 cites W2163212976 @default.
- W2034831859 cites W2165627850 @default.
- W2034831859 cites W2218756884 @default.
- W2034831859 cites W2490887501 @default.
- W2034831859 doi "https://doi.org/10.1080/152873901316981312" @default.
- W2034831859 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11693491" @default.
- W2034831859 hasPublicationYear "2001" @default.
- W2034831859 type Work @default.
- W2034831859 sameAs 2034831859 @default.
- W2034831859 citedByCount "107" @default.
- W2034831859 countsByYear W20348318592012 @default.
- W2034831859 countsByYear W20348318592013 @default.
- W2034831859 countsByYear W20348318592014 @default.
- W2034831859 countsByYear W20348318592015 @default.
- W2034831859 countsByYear W20348318592016 @default.
- W2034831859 countsByYear W20348318592017 @default.
- W2034831859 countsByYear W20348318592018 @default.
- W2034831859 countsByYear W20348318592019 @default.
- W2034831859 countsByYear W20348318592020 @default.
- W2034831859 countsByYear W20348318592021 @default.
- W2034831859 countsByYear W20348318592022 @default.
- W2034831859 countsByYear W20348318592023 @default.
- W2034831859 crossrefType "journal-article" @default.
- W2034831859 hasAuthorship W2034831859A5017259921 @default.
- W2034831859 hasAuthorship W2034831859A5025927483 @default.
- W2034831859 hasAuthorship W2034831859A5031750107 @default.
- W2034831859 hasAuthorship W2034831859A5056294730 @default.
- W2034831859 hasAuthorship W2034831859A5067831607 @default.
- W2034831859 hasAuthorship W2034831859A5084079702 @default.
- W2034831859 hasConcept C104317684 @default.
- W2034831859 hasConcept C126322002 @default.
- W2034831859 hasConcept C131783052 @default.
- W2034831859 hasConcept C134018914 @default.
- W2034831859 hasConcept C2777714996 @default.
- W2034831859 hasConcept C2778206080 @default.
- W2034831859 hasConcept C2780091579 @default.
- W2034831859 hasConcept C2780266248 @default.
- W2034831859 hasConcept C2780931953 @default.
- W2034831859 hasConcept C2781040948 @default.
- W2034831859 hasConcept C2781087480 @default.
- W2034831859 hasConcept C2781254305 @default.
- W2034831859 hasConcept C33594762 @default.
- W2034831859 hasConcept C55493867 @default.
- W2034831859 hasConcept C59822182 @default.
- W2034831859 hasConcept C71924100 @default.
- W2034831859 hasConcept C77411442 @default.
- W2034831859 hasConcept C83974742 @default.
- W2034831859 hasConcept C86339819 @default.
- W2034831859 hasConcept C86803240 @default.
- W2034831859 hasConceptScore W2034831859C104317684 @default.
- W2034831859 hasConceptScore W2034831859C126322002 @default.
- W2034831859 hasConceptScore W2034831859C131783052 @default.
- W2034831859 hasConceptScore W2034831859C134018914 @default.
- W2034831859 hasConceptScore W2034831859C2777714996 @default.
- W2034831859 hasConceptScore W2034831859C2778206080 @default.
- W2034831859 hasConceptScore W2034831859C2780091579 @default.
- W2034831859 hasConceptScore W2034831859C2780266248 @default.
- W2034831859 hasConceptScore W2034831859C2780931953 @default.
- W2034831859 hasConceptScore W2034831859C2781040948 @default.
- W2034831859 hasConceptScore W2034831859C2781087480 @default.
- W2034831859 hasConceptScore W2034831859C2781254305 @default.
- W2034831859 hasConceptScore W2034831859C33594762 @default.
- W2034831859 hasConceptScore W2034831859C55493867 @default.
- W2034831859 hasConceptScore W2034831859C59822182 @default.
- W2034831859 hasConceptScore W2034831859C71924100 @default.
- W2034831859 hasConceptScore W2034831859C77411442 @default.
- W2034831859 hasConceptScore W2034831859C83974742 @default.
- W2034831859 hasConceptScore W2034831859C86339819 @default.
- W2034831859 hasConceptScore W2034831859C86803240 @default.
- W2034831859 hasIssue "4" @default.