FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034831937> ?p ?o ?g. }

• W2034831937 abstract "Abstract Cne1p is a yeast homolog of calnexin, which is a constituent of endoplasmic reticulum (ER)-associated protein quality control system in mammals. Cne1p may be involved in the degradation of misfolded lysozymes in Saccharomyces cerevisiae. To test this, c-Myc-tagged lysozymes were expressed in CNE1-deficient S. cerevisiae. The expression and secretion of an unstable lysozyme mutant G49N/D66H were enhanced and its intracellular localization was changed in the CNE1-deficient strain. Furthermore, when Cne1p was co-expressed with unstable lysozyme mutants (G49N/D66H, G49N/C76A, and K13D/G49N), its affinity to the misfolded mutant proteins was revealed by co-immunoprecipitation. The interaction with Cne1p was abrogated by the addition of tunicamycin, an inhibitor of N-glycosylation, indicating that N-linked carbohydrates might be necessary for protein binding to Cne1p. These results suggest that in yeasts, Cne1p interacts with misfolded lysozyme proteins possibly causing their retention in the ER and subsequent elimination via ER-associated degradation." @default.
• W2034831937 created "2016-06-24" @default.
• W2034831937 creator A5011720105 @default.
• W2034831937 creator A5014533999 @default.
• W2034831937 creator A5022912496 @default.
• W2034831937 creator A5029029825 @default.
• W2034831937 creator A5035008197 @default.
• W2034831937 creator A5038400717 @default.
• W2034831937 creator A5051089207 @default.
• W2034831937 date "2014-07-03" @default.
• W2034831937 modified "2023-09-26" @default.
• W2034831937 title "Unstable mutant lysozymes are degraded through the interaction with calnexin homolog Cne1p in Saccharomyces cerevisiae" @default.
• W2034831937 cites W1502392336 @default.
• W2034831937 cites W1964225173 @default.
• W2034831937 cites W1976482695 @default.
• W2034831937 cites W1983504336 @default.
• W2034831937 cites W2006690805 @default.
• W2034831937 cites W2008001792 @default.
• W2034831937 cites W2009160701 @default.
• W2034831937 cites W2012455318 @default.
• W2034831937 cites W2033876560 @default.
• W2034831937 cites W2035391351 @default.
• W2034831937 cites W2038303530 @default.
• W2034831937 cites W2062290955 @default.
• W2034831937 cites W2068586920 @default.
• W2034831937 cites W2091797397 @default.
• W2034831937 cites W2108496927 @default.
• W2034831937 cites W2111177083 @default.
• W2034831937 cites W2121217914 @default.
• W2034831937 cites W2163828149 @default.
• W2034831937 doi "https://doi.org/10.1080/09168451.2014.918486" @default.
• W2034831937 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25229868" @default.
• W2034831937 hasPublicationYear "2014" @default.
• W2034831937 type Work @default.
• W2034831937 sameAs 2034831937 @default.
• W2034831937 citedByCount "1" @default.
• W2034831937 countsByYear W20348319372015 @default.
• W2034831937 crossrefType "journal-article" @default.
• W2034831937 hasAuthorship W2034831937A5011720105 @default.
• W2034831937 hasAuthorship W2034831937A5014533999 @default.
• W2034831937 hasAuthorship W2034831937A5022912496 @default.
• W2034831937 hasAuthorship W2034831937A5029029825 @default.
• W2034831937 hasAuthorship W2034831937A5035008197 @default.
• W2034831937 hasAuthorship W2034831937A5038400717 @default.
• W2034831937 hasAuthorship W2034831937A5051089207 @default.
• W2034831937 hasBestOaLocation W20348319371 @default.
• W2034831937 hasConcept C104317684 @default.
• W2034831937 hasConcept C130361206 @default.
• W2034831937 hasConcept C139447449 @default.
• W2034831937 hasConcept C143065580 @default.
• W2034831937 hasConcept C153911025 @default.
• W2034831937 hasConcept C158617107 @default.
• W2034831937 hasConcept C158619295 @default.
• W2034831937 hasConcept C185592680 @default.
• W2034831937 hasConcept C204328495 @default.
• W2034831937 hasConcept C2776966407 @default.
• W2034831937 hasConcept C2777313579 @default.
• W2034831937 hasConcept C2777575526 @default.
• W2034831937 hasConcept C2777576037 @default.
• W2034831937 hasConcept C2779222958 @default.
• W2034831937 hasConcept C2779926675 @default.
• W2034831937 hasConcept C47450691 @default.
• W2034831937 hasConcept C55493867 @default.
• W2034831937 hasConcept C71829478 @default.
• W2034831937 hasConcept C86803240 @default.
• W2034831937 hasConcept C95444343 @default.
• W2034831937 hasConceptScore W2034831937C104317684 @default.
• W2034831937 hasConceptScore W2034831937C130361206 @default.
• W2034831937 hasConceptScore W2034831937C139447449 @default.
• W2034831937 hasConceptScore W2034831937C143065580 @default.
• W2034831937 hasConceptScore W2034831937C153911025 @default.
• W2034831937 hasConceptScore W2034831937C158617107 @default.
• W2034831937 hasConceptScore W2034831937C158619295 @default.
• W2034831937 hasConceptScore W2034831937C185592680 @default.
• W2034831937 hasConceptScore W2034831937C204328495 @default.
• W2034831937 hasConceptScore W2034831937C2776966407 @default.
• W2034831937 hasConceptScore W2034831937C2777313579 @default.
• W2034831937 hasConceptScore W2034831937C2777575526 @default.
• W2034831937 hasConceptScore W2034831937C2777576037 @default.
• W2034831937 hasConceptScore W2034831937C2779222958 @default.
• W2034831937 hasConceptScore W2034831937C2779926675 @default.
• W2034831937 hasConceptScore W2034831937C47450691 @default.
• W2034831937 hasConceptScore W2034831937C55493867 @default.
• W2034831937 hasConceptScore W2034831937C71829478 @default.
• W2034831937 hasConceptScore W2034831937C86803240 @default.
• W2034831937 hasConceptScore W2034831937C95444343 @default.
• W2034831937 hasLocation W20348319371 @default.
• W2034831937 hasLocation W20348319372 @default.
• W2034831937 hasOpenAccess W2034831937 @default.
• W2034831937 hasPrimaryLocation W20348319371 @default.
• W2034831937 hasRelatedWork W1555564714 @default.
• W2034831937 hasRelatedWork W1865199207 @default.
• W2034831937 hasRelatedWork W1966351650 @default.
• W2034831937 hasRelatedWork W1969120566 @default.
• W2034831937 hasRelatedWork W1971302334 @default.
• W2034831937 hasRelatedWork W1985379888 @default.
• W2034831937 hasRelatedWork W1995597302 @default.
• W2034831937 hasRelatedWork W2000078932 @default.
• W2034831937 hasRelatedWork W2008001792 @default.
• W2034831937 hasRelatedWork W2010241698 @default.

• next