FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034841837> ?p ?o ?g. }

• W2034841837 endingPage "1230" @default.
• W2034841837 startingPage "1221" @default.
• W2034841837 abstract "The mammary glands develop initially as buds arising from the ventral embryonic epidermis. Recent work has shed light on signaling pathways leading to the patterning and formation of the mammary placodes and buds in mouse embryos. Relatively little is known of the signaling pathways that initiate branching morphogenesis and the formation of the ducts from the embryonic buds. Previous studies have shown that parathyroid hormone-related protein(PTHrP; also known as parathyroid hormone-like peptide, Pthlh) is produced by mammary epithelial cells and acts on surrounding mesenchymal cells to promote their differentiation into a mammary-specific dense mesenchyme. As a result of PTHrP signaling, the mammary mesenchyme supports mammary epithelial cell fate,initiates ductal development and patterns the overlying nipple sheath. In this report, we demonstrate that PTHrP acts, in part, by sensitizing mesenchymal cells to BMP signaling. PTHrP upregulates BMP receptor 1A expression in the mammary mesenchyme, enabling it to respond to BMP4, which is expressed within mesenchymal cells underlying the ventral epidermis during mammary bud formation. We demonstrate that BMP signaling is important for outgrowth of normal mammary buds and that BMP4 can rescue outgrowth of PTHrP-/-mammary buds. In addition, the combination of PTHrP and BMP signaling is responsible for upregulating Msx2 gene expression within the mammary mesenchyme, and disruption of the Msx2 gene rescues the induction of hair follicles on the ventral surface of mice overexpressing PTHrP in keratinocytes (K14-PTHrP). Our data suggest that PTHrP signaling sensitizes the mammary mesenchyme to the actions of BMP4, triggering outgrowth of the mammary buds and inducing MSX2 expression, which, in turn, leads to lateral inhibition of hair follicle formation within the developing nipple sheath." @default.
• W2034841837 created "2016-06-24" @default.
• W2034841837 creator A5062154626 @default.
• W2034841837 creator A5064020974 @default.
• W2034841837 creator A5069142714 @default.
• W2034841837 creator A5070258179 @default.
• W2034841837 creator A5088260235 @default.
• W2034841837 creator A5090651758 @default.
• W2034841837 date "2007-03-15" @default.
• W2034841837 modified "2023-10-16" @default.
• W2034841837 title "BMP4 and PTHrP interact to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction" @default.
• W2034841837 cites W134066139 @default.
• W2034841837 cites W1532399084 @default.
• W2034841837 cites W1541819796 @default.
• W2034841837 cites W1549695464 @default.
• W2034841837 cites W1720193968 @default.
• W2034841837 cites W1757679215 @default.
• W2034841837 cites W194402960 @default.
• W2034841837 cites W1964467849 @default.
• W2034841837 cites W1968093456 @default.
• W2034841837 cites W1971005593 @default.
• W2034841837 cites W1974287326 @default.
• W2034841837 cites W1976213734 @default.
• W2034841837 cites W1979518793 @default.
• W2034841837 cites W1981839439 @default.
• W2034841837 cites W1998733764 @default.
• W2034841837 cites W2009900140 @default.
• W2034841837 cites W2010617516 @default.
• W2034841837 cites W2013575704 @default.
• W2034841837 cites W2018631055 @default.
• W2034841837 cites W2020250544 @default.
• W2034841837 cites W2024400655 @default.
• W2034841837 cites W2027593708 @default.
• W2034841837 cites W2039813962 @default.
• W2034841837 cites W2040101029 @default.
• W2034841837 cites W2040805114 @default.
• W2034841837 cites W2046484024 @default.
• W2034841837 cites W2047628030 @default.
• W2034841837 cites W2048830857 @default.
• W2034841837 cites W2050650124 @default.
• W2034841837 cites W2051580972 @default.
• W2034841837 cites W2054439316 @default.
• W2034841837 cites W2055416616 @default.
• W2034841837 cites W2058004364 @default.
• W2034841837 cites W2059030354 @default.
• W2034841837 cites W2068169334 @default.
• W2034841837 cites W2068227259 @default.
• W2034841837 cites W2070470162 @default.
• W2034841837 cites W2073552393 @default.
• W2034841837 cites W2077690851 @default.
• W2034841837 cites W2088568448 @default.
• W2034841837 cites W2097923096 @default.
• W2034841837 cites W2098686183 @default.
• W2034841837 cites W2105943764 @default.
• W2034841837 cites W2107353510 @default.
• W2034841837 cites W2114990515 @default.
• W2034841837 cites W2120045068 @default.
• W2034841837 cites W2132650229 @default.
• W2034841837 cites W2144008094 @default.
• W2034841837 cites W2144459502 @default.
• W2034841837 cites W2145032231 @default.
• W2034841837 cites W2158648950 @default.
• W2034841837 cites W2168169424 @default.
• W2034841837 cites W2170396713 @default.
• W2034841837 cites W2304796709 @default.
• W2034841837 cites W56952916 @default.
• W2034841837 doi "https://doi.org/10.1242/dev.000182" @default.
• W2034841837 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17301089" @default.
• W2034841837 hasPublicationYear "2007" @default.
• W2034841837 type Work @default.
• W2034841837 sameAs 2034841837 @default.
• W2034841837 citedByCount "112" @default.
• W2034841837 countsByYear W20348418372012 @default.
• W2034841837 countsByYear W20348418372013 @default.
• W2034841837 countsByYear W20348418372014 @default.
• W2034841837 countsByYear W20348418372015 @default.
• W2034841837 countsByYear W20348418372016 @default.
• W2034841837 countsByYear W20348418372017 @default.
• W2034841837 countsByYear W20348418372018 @default.
• W2034841837 countsByYear W20348418372019 @default.
• W2034841837 countsByYear W20348418372020 @default.
• W2034841837 countsByYear W20348418372021 @default.
• W2034841837 countsByYear W20348418372022 @default.
• W2034841837 countsByYear W20348418372023 @default.
• W2034841837 crossrefType "journal-article" @default.
• W2034841837 hasAuthorship W2034841837A5062154626 @default.
• W2034841837 hasAuthorship W2034841837A5064020974 @default.
• W2034841837 hasAuthorship W2034841837A5069142714 @default.
• W2034841837 hasAuthorship W2034841837A5070258179 @default.
• W2034841837 hasAuthorship W2034841837A5088260235 @default.
• W2034841837 hasAuthorship W2034841837A5090651758 @default.
• W2034841837 hasConcept C104317684 @default.
• W2034841837 hasConcept C121608353 @default.
• W2034841837 hasConcept C126322002 @default.
• W2034841837 hasConcept C134018914 @default.
• W2034841837 hasConcept C145103041 @default.
• W2034841837 hasConcept C198826908 @default.
• W2034841837 hasConcept C2776340970 @default.

• next