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- W2034842761 abstract "Functionalized mesoporous bioactive glasses (MBG) with photoactive coumarin demonstrates photo-responsive dimerization resulting in reversible gate operation. Coumarin-modified MBG was used as a drug delivery carrier to investigate drug storage/release characteristics using phenanthrene as a model drug. Irradiation with UV light (>310 nm) induced photo-dimerization of the coumarin-modified MBG, which led to the pores' closing with cyclobutane dimers and trapping of the guest phenanthrene in the mesopores. However, irradiating the dimerized-coumarin-modified MBG with shorter wavelength UV light (approximately 250 nm) regenerates the coumarin monomer derivative by the photo-cleavage of cyclobutane dimers, such that trapped guest molecules are released from the mesopores. The structural, morphological, textural and optical properties are well characterized by X-ray diffraction, transmission electron microscopy, N(2) adsorption/desorption, and UV-visible spectroscopy. The results reveal that the MBG exhibits the typical ordered characteristics of the hexagonal mesostructure. The system demonstrates great potential in light-sensitive intelligent drug delivery systems and disease therapy fields." @default.
- W2034842761 created "2016-06-24" @default.
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- W2034842761 date "2010-08-01" @default.
- W2034842761 modified "2023-09-26" @default.
- W2034842761 title "Light-sensitive intelligent drug delivery systems of coumarin-modified mesoporous bioactive glass" @default.
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- W2034842761 doi "https://doi.org/10.1016/j.actbio.2010.02.014" @default.
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