Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034843514> ?p ?o ?g. }
- W2034843514 endingPage "56" @default.
- W2034843514 startingPage "48" @default.
- W2034843514 abstract "Type 2 diabetes mellitus (T2DM) is a polygenetic disease. Its incidence is increasing continuously in Taiwan as the standard of living improves. Current diabetes research is striving to identify those high at risk of T2DM through T2DM- associated gene studies. A number of techniques are available for the molecular detection of T2DM-associated genes, including polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP), direct sequencing, and TaqMan genotyping. However, they are capable of analyzing only one molecular target in each experiment. In the present study, we selected eight candidate genes that are potentially associated with T2DM [angiotensinogen (AGT), sulfonylurea receptor-1 (SUR-1), peroxisome proliferators-activated receptor-γ (PPAR-γ), PPAR-γ coactivator-1 (PGC-1), calpain-10 (CAPN10), β2-adrenergic receptor (ADRB2), mannose-binding lectin (MBL2), and insulin receptor substrate-1 (IRS-1)]. We used enzymatic chip array technology, which we had previously established, and analyzed its relevance to diabetes research. We enrolled 1280 Taiwanese patients (700 with T2DM and 580 non-diabetic controls). The genes of all subjects were analyzed by the enzymatic chip array. The results were consistent with direct sequencing. On the basis of multivariate logistic-regression analysis—with adjustment for age—the following variables were associated with a significant risk of T2DM: body mass index, serum cholesterol, triglyceride level, low- and high-density lipoprotein cholesterol levels, and polymorphisms, including PGC-1 Gly482Ser, SUR1 Arg1273Arg, ADRB2 Arg16Gly, CAPN10 SNP43, AGT Met235Thr, and MLB2 Gly54Asp. The enzymatic chip array is a useful tool for multiple gene analysis in diabetes." @default.
- W2034843514 created "2016-06-24" @default.
- W2034843514 creator A5000297562 @default.
- W2034843514 creator A5001181013 @default.
- W2034843514 creator A5013724444 @default.
- W2034843514 creator A5026887457 @default.
- W2034843514 creator A5029394685 @default.
- W2034843514 creator A5037925897 @default.
- W2034843514 creator A5049658299 @default.
- W2034843514 creator A5050096159 @default.
- W2034843514 date "2009-08-01" @default.
- W2034843514 modified "2023-09-27" @default.
- W2034843514 title "A New Technique—Simultaneously Detecting Multiple Genetic Polymorphisms of Type 2 Diabetes- associated Genes by the Enzymatic Chip Array" @default.
- W2034843514 cites W114518569 @default.
- W2034843514 cites W1483738250 @default.
- W2034843514 cites W1531269910 @default.
- W2034843514 cites W1963936426 @default.
- W2034843514 cites W1965672218 @default.
- W2034843514 cites W2005498344 @default.
- W2034843514 cites W2019405117 @default.
- W2034843514 cites W2038902693 @default.
- W2034843514 cites W2042103448 @default.
- W2034843514 cites W2055842728 @default.
- W2034843514 cites W2069038045 @default.
- W2034843514 cites W2077464018 @default.
- W2034843514 cites W2077748449 @default.
- W2034843514 cites W2088948992 @default.
- W2034843514 cites W2094303107 @default.
- W2034843514 cites W2101338071 @default.
- W2034843514 cites W2104888242 @default.
- W2034843514 cites W2110649443 @default.
- W2034843514 cites W2114920731 @default.
- W2034843514 cites W2120390577 @default.
- W2034843514 cites W2130067148 @default.
- W2034843514 cites W2131237363 @default.
- W2034843514 cites W2132984312 @default.
- W2034843514 cites W2133194323 @default.
- W2034843514 cites W2142123049 @default.
- W2034843514 cites W2143929930 @default.
- W2034843514 cites W2146756601 @default.
- W2034843514 cites W2146900230 @default.
- W2034843514 cites W2160740604 @default.
- W2034843514 cites W2161381121 @default.
- W2034843514 cites W2162088190 @default.
- W2034843514 cites W2407867250 @default.
- W2034843514 cites W2419398700 @default.
- W2034843514 doi "https://doi.org/10.1016/s1877-8607(09)60008-4" @default.
- W2034843514 hasPublicationYear "2009" @default.
- W2034843514 type Work @default.
- W2034843514 sameAs 2034843514 @default.
- W2034843514 citedByCount "0" @default.
- W2034843514 crossrefType "journal-article" @default.
- W2034843514 hasAuthorship W2034843514A5000297562 @default.
- W2034843514 hasAuthorship W2034843514A5001181013 @default.
- W2034843514 hasAuthorship W2034843514A5013724444 @default.
- W2034843514 hasAuthorship W2034843514A5026887457 @default.
- W2034843514 hasAuthorship W2034843514A5029394685 @default.
- W2034843514 hasAuthorship W2034843514A5037925897 @default.
- W2034843514 hasAuthorship W2034843514A5049658299 @default.
- W2034843514 hasAuthorship W2034843514A5050096159 @default.
- W2034843514 hasConcept C104317684 @default.
- W2034843514 hasConcept C126322002 @default.
- W2034843514 hasConcept C134018914 @default.
- W2034843514 hasConcept C135763542 @default.
- W2034843514 hasConcept C2910068830 @default.
- W2034843514 hasConcept C31467283 @default.
- W2034843514 hasConcept C54355233 @default.
- W2034843514 hasConcept C555293320 @default.
- W2034843514 hasConcept C71924100 @default.
- W2034843514 hasConcept C86803240 @default.
- W2034843514 hasConceptScore W2034843514C104317684 @default.
- W2034843514 hasConceptScore W2034843514C126322002 @default.
- W2034843514 hasConceptScore W2034843514C134018914 @default.
- W2034843514 hasConceptScore W2034843514C135763542 @default.
- W2034843514 hasConceptScore W2034843514C2910068830 @default.
- W2034843514 hasConceptScore W2034843514C31467283 @default.
- W2034843514 hasConceptScore W2034843514C54355233 @default.
- W2034843514 hasConceptScore W2034843514C555293320 @default.
- W2034843514 hasConceptScore W2034843514C71924100 @default.
- W2034843514 hasConceptScore W2034843514C86803240 @default.
- W2034843514 hasIssue "1" @default.
- W2034843514 hasLocation W20348435141 @default.
- W2034843514 hasOpenAccess W2034843514 @default.
- W2034843514 hasPrimaryLocation W20348435141 @default.
- W2034843514 hasRelatedWork W2049974637 @default.
- W2034843514 hasRelatedWork W2119121134 @default.
- W2034843514 hasRelatedWork W2125102063 @default.
- W2034843514 hasRelatedWork W2127396703 @default.
- W2034843514 hasRelatedWork W2248968970 @default.
- W2034843514 hasRelatedWork W2383292550 @default.
- W2034843514 hasRelatedWork W2587207072 @default.
- W2034843514 hasRelatedWork W2796825901 @default.
- W2034843514 hasRelatedWork W3125003865 @default.
- W2034843514 hasRelatedWork W4254606819 @default.
- W2034843514 hasVolume "1" @default.
- W2034843514 isParatext "false" @default.
- W2034843514 isRetracted "false" @default.
- W2034843514 magId "2034843514" @default.