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- W2034846079 endingPage "50" @default.
- W2034846079 startingPage "36" @default.
- W2034846079 abstract "Oxidative stress is a key mechanism causing protein aggregation, cell death and neurodegeneration in the nervous system. The neuronal cytoskeleton, that is, microtubules, actin filaments and neurofilaments, plays a key role in defending the nervous system against oxidative stress-induced damage and is also a target for this damage itself. Microtubules appear particularly susceptible to damage, with oxidative stress downregulating key microtubule-associated proteins [MAPs] and affecting tubulin through aberrant post-translational modifications. Actin filaments utilise oxidative stress for their reorganisation and thus may be less susceptible to deleterious effects. However, because cytoskeletal components are interconnected through crosslinking proteins, damage to one component affects the entire cytoskeletal network. Neurofilaments are phosphorylated under oxidative stress, leading to the formation of protein aggregates reminiscent of those seen in neurodegenerative diseases. Drugs that target the cytoskeleton may thus be of great use in treating various neurodegenerative diseases caused by oxidative stress." @default.
- W2034846079 created "2016-06-24" @default.
- W2034846079 creator A5004461484 @default.
- W2034846079 creator A5032583650 @default.
- W2034846079 creator A5041201830 @default.
- W2034846079 date "2013-10-21" @default.
- W2034846079 modified "2023-10-18" @default.
- W2034846079 title "The Nervous System Cytoskeleton under Oxidative Stress" @default.
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- W2034846079 doi "https://doi.org/10.3390/diseases1010036" @default.
- W2034846079 hasPublicationYear "2013" @default.
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