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• W2034846575 endingPage "95" @default.
• W2034846575 startingPage "84" @default.
• W2034846575 abstract "Lateral superior olive (LSO) neurons in young and aged Sprague-Dawley rats have functional properties consistent with a limited contralateral inhibition, which is markedly different from other animals. An unusually low proportion of LSO cells (36113) exhibited contralateral inhibition (and ipsilateral excitation, IE), while over 25% of LSO units exhibited excitatory responses to contralateral stimuli. Inhibition of most IE LSO neurons was evident only when the contralateral intensity was greater than the ipsilateral intensity, resulting in a marked shift in sensitivity to interaural intensity differences (IID). The firing rate of IE neurons was also affected more by a change in intensity of ipsilateral compared to contralateral stimuli. The shift in the IID sensitivity and the relative decrease in effectiveness of contralaterally driven inhibition in Sprague-Dawley rat LSO neurons could be due to decreased inhibitory inputs from the MNTB principal cells, increased contralateral excitatory effects and/or increased ipsilateral excitatory effects. Age-related decreases in the numbers of MNTB neurons observed anatomically is not reflected in a change in LSO function. The Sprague-Dawley rat may be a useful model for the effect of reduced inhibition in the superior olivary complex on auditory behavior." @default.
• W2034846575 created "2016-06-24" @default.
• W2034846575 creator A5010913982 @default.
• W2034846575 date "1995-07-01" @default.
• W2034846575 modified "2023-10-16" @default.
• W2034846575 title "Decreased inhibition to lateral superior olive neurons in young and aged Sprague-Dawley rats" @default.
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• W2034846575 doi "https://doi.org/10.1016/0378-5955(95)00081-e" @default.
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• W2034846575 hasPublicationYear "1995" @default.
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