Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034847029> ?p ?o ?g. }
Showing items 1 to 91 of
91
with 100 items per page.
- W2034847029 endingPage "78" @default.
- W2034847029 startingPage "71" @default.
- W2034847029 abstract "Abstract The polycyclic aromatic hydrocarbon (PAH) dibenzo[a, l]pyrene (DB[a, l]P) has been found to be an environmental pollutant and, considering the available data from rodent bioassays, it represents the most carcinogenic member compound of the class of PAH yet discovered. To sort out the contribution of individual cytochromes P450 (P450) in the metabolic activation of this PAH, V79 cells stably expressing a single P450 isoform were treated with DB[a, l]P or enantiomeric DB[a, l]P-11,12-dihydrodiols (diols). Subsequent analysis of the DNA adducts formed revealed substantial differences in the adduct pattern and the total DNA binding depending on the cell line used. Human P450 1B1 effectively activated 0.1 μM DB[a, l]P (350 pmol adducts/mg DNA) and 0.05 μM (-)-(R,R)-diol (1010 pmol/mg DNA). Human P450 1A1 and rat P450 1A1 were less effective than human 1B1 in activating 0.1 μM DB[a, l]P (27 and 28 pmol/mg DNA, respectively), but significantly more active than human 3A4, human 2A6, and rat 1A2 (0.1, 0.2, and 17 pmol adducts/mg DNA after treatment with 1.0 μM PAH, respectively). Although the activation of the (+)-(S,S)-diol was low in all cases, it could be responsible for a substantial fraction of total DNA binding with P450 isoforms that had only a limited ability to activate DB[a, l]P (e.g. human 2A6, rat 1A2, or rat 2B1)." @default.
- W2034847029 created "2016-06-24" @default.
- W2034847029 creator A5005244675 @default.
- W2034847029 creator A5026277311 @default.
- W2034847029 creator A5027654298 @default.
- W2034847029 creator A5042094715 @default.
- W2034847029 creator A5074547704 @default.
- W2034847029 creator A5079625917 @default.
- W2034847029 date "2000-06-01" @default.
- W2034847029 modified "2023-10-03" @default.
- W2034847029 title "DNA Modification Induced After Metabolic Activation of the Potent Carcinogen Dibenzo[a, l]pyrene in V79 Chinese Hamster Cells Stably Expressing Single Cytochromes P450" @default.
- W2034847029 cites W1989734490 @default.
- W2034847029 cites W1994642683 @default.
- W2034847029 cites W1996033279 @default.
- W2034847029 cites W2001098153 @default.
- W2034847029 cites W2004988801 @default.
- W2034847029 cites W2017159222 @default.
- W2034847029 cites W2022447460 @default.
- W2034847029 cites W2047878898 @default.
- W2034847029 cites W2054114446 @default.
- W2034847029 cites W2054836547 @default.
- W2034847029 cites W2056939737 @default.
- W2034847029 cites W2077018913 @default.
- W2034847029 cites W2079542036 @default.
- W2034847029 cites W2085738604 @default.
- W2034847029 cites W2091430075 @default.
- W2034847029 cites W2148821777 @default.
- W2034847029 cites W2396843460 @default.
- W2034847029 doi "https://doi.org/10.1080/10406639908020574" @default.
- W2034847029 hasPublicationYear "2000" @default.
- W2034847029 type Work @default.
- W2034847029 sameAs 2034847029 @default.
- W2034847029 citedByCount "0" @default.
- W2034847029 crossrefType "journal-article" @default.
- W2034847029 hasAuthorship W2034847029A5005244675 @default.
- W2034847029 hasAuthorship W2034847029A5026277311 @default.
- W2034847029 hasAuthorship W2034847029A5027654298 @default.
- W2034847029 hasAuthorship W2034847029A5042094715 @default.
- W2034847029 hasAuthorship W2034847029A5074547704 @default.
- W2034847029 hasAuthorship W2034847029A5079625917 @default.
- W2034847029 hasConcept C104317684 @default.
- W2034847029 hasConcept C108204754 @default.
- W2034847029 hasConcept C114246631 @default.
- W2034847029 hasConcept C143425029 @default.
- W2034847029 hasConcept C153911025 @default.
- W2034847029 hasConcept C178790620 @default.
- W2034847029 hasConcept C185592680 @default.
- W2034847029 hasConcept C2777538855 @default.
- W2034847029 hasConcept C2777755551 @default.
- W2034847029 hasConcept C2778951431 @default.
- W2034847029 hasConcept C53345823 @default.
- W2034847029 hasConcept C552990157 @default.
- W2034847029 hasConcept C55493867 @default.
- W2034847029 hasConcept C71240020 @default.
- W2034847029 hasConcept C86803240 @default.
- W2034847029 hasConceptScore W2034847029C104317684 @default.
- W2034847029 hasConceptScore W2034847029C108204754 @default.
- W2034847029 hasConceptScore W2034847029C114246631 @default.
- W2034847029 hasConceptScore W2034847029C143425029 @default.
- W2034847029 hasConceptScore W2034847029C153911025 @default.
- W2034847029 hasConceptScore W2034847029C178790620 @default.
- W2034847029 hasConceptScore W2034847029C185592680 @default.
- W2034847029 hasConceptScore W2034847029C2777538855 @default.
- W2034847029 hasConceptScore W2034847029C2777755551 @default.
- W2034847029 hasConceptScore W2034847029C2778951431 @default.
- W2034847029 hasConceptScore W2034847029C53345823 @default.
- W2034847029 hasConceptScore W2034847029C552990157 @default.
- W2034847029 hasConceptScore W2034847029C55493867 @default.
- W2034847029 hasConceptScore W2034847029C71240020 @default.
- W2034847029 hasConceptScore W2034847029C86803240 @default.
- W2034847029 hasIssue "1-4" @default.
- W2034847029 hasLocation W20348470291 @default.
- W2034847029 hasOpenAccess W2034847029 @default.
- W2034847029 hasPrimaryLocation W20348470291 @default.
- W2034847029 hasRelatedWork W1964025682 @default.
- W2034847029 hasRelatedWork W1972397196 @default.
- W2034847029 hasRelatedWork W1992744358 @default.
- W2034847029 hasRelatedWork W1996296647 @default.
- W2034847029 hasRelatedWork W1997248328 @default.
- W2034847029 hasRelatedWork W2047436289 @default.
- W2034847029 hasRelatedWork W2055685382 @default.
- W2034847029 hasRelatedWork W2226624016 @default.
- W2034847029 hasRelatedWork W2414596920 @default.
- W2034847029 hasRelatedWork W2284936231 @default.
- W2034847029 hasVolume "16" @default.
- W2034847029 isParatext "false" @default.
- W2034847029 isRetracted "false" @default.
- W2034847029 magId "2034847029" @default.
- W2034847029 workType "article" @default.