FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034847524> ?p ?o ?g. }

• W2034847524 endingPage "974" @default.
• W2034847524 startingPage "967" @default.
• W2034847524 abstract "Although inversions have occasionally been found to be associated with disease susceptibility through interrupting a gene or its regulatory region, or by increasing the risk for deleterious secondary rearrangements, no association study has been specifically conducted for risks associated with inversions, mainly because existing approaches to detecting and genotyping inversions do not readily scale to a large number of samples. Based on our recently proposed approach to identifying and genotyping inversions using principal components analysis (PCA), we herein develop a method of detecting association between inversions and disease in a genome-wide fashion. Our method uses genotype data for single nucleotide polymorphisms (SNPs), and is thus cost-efficient and computationally fast. For an inversion polymorphism, local PCA around the inversion region is performed to infer the inversion genotypes of all samples. For many inversions, we found that some of the SNPs inside an inversion region are fixed in the two lineages of different orientations and thus can serve as surrogate markers. Our method can be applied to case-control and quantitative trait association studies to identify inversions that may interrupt a gene or the connection between a gene and its regulatory agents. Our method also offers a new venue to identify inversions that are responsible for disease-causing secondary rearrangements. We illustrated our proposed approach to case-control data for psoriasis and identified novel associations with a few inversion polymorphisms." @default.
• W2034847524 created "2016-06-24" @default.
• W2034847524 creator A5008447766 @default.
• W2034847524 creator A5017745566 @default.
• W2034847524 creator A5028989565 @default.
• W2034847524 creator A5061594020 @default.
• W2034847524 creator A5076622040 @default.
• W2034847524 date "2014-03-13" @default.
• W2034847524 modified "2023-10-17" @default.
• W2034847524 title "Genome-wide association tests of inversions with application to psoriasis" @default.
• W2034847524 cites W1686085663 @default.
• W2034847524 cites W1700997260 @default.
• W2034847524 cites W1980991473 @default.
• W2034847524 cites W1981924240 @default.
• W2034847524 cites W1982998516 @default.
• W2034847524 cites W1991922215 @default.
• W2034847524 cites W1993983922 @default.
• W2034847524 cites W1996197535 @default.
• W2034847524 cites W2000193624 @default.
• W2034847524 cites W2013034328 @default.
• W2034847524 cites W2013221974 @default.
• W2034847524 cites W2018775283 @default.
• W2034847524 cites W2024975965 @default.
• W2034847524 cites W2032247293 @default.
• W2034847524 cites W2043882061 @default.
• W2034847524 cites W2050889567 @default.
• W2034847524 cites W2052218777 @default.
• W2034847524 cites W2053600190 @default.
• W2034847524 cites W2058401000 @default.
• W2034847524 cites W2065817684 @default.
• W2034847524 cites W2072591969 @default.
• W2034847524 cites W2123871174 @default.
• W2034847524 cites W2130407782 @default.
• W2034847524 cites W2133374479 @default.
• W2034847524 cites W2135949952 @default.
• W2034847524 cites W2140869203 @default.
• W2034847524 cites W2160261558 @default.
• W2034847524 cites W2167638767 @default.
• W2034847524 cites W2169405380 @default.
• W2034847524 doi "https://doi.org/10.1007/s00439-014-1437-1" @default.
• W2034847524 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4281304" @default.
• W2034847524 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24623382" @default.
• W2034847524 hasPublicationYear "2014" @default.
• W2034847524 type Work @default.
• W2034847524 sameAs 2034847524 @default.
• W2034847524 citedByCount "11" @default.
• W2034847524 countsByYear W20348475242015 @default.
• W2034847524 countsByYear W20348475242016 @default.
• W2034847524 countsByYear W20348475242018 @default.
• W2034847524 countsByYear W20348475242019 @default.
• W2034847524 countsByYear W20348475242020 @default.
• W2034847524 countsByYear W20348475242022 @default.
• W2034847524 crossrefType "journal-article" @default.
• W2034847524 hasAuthorship W2034847524A5008447766 @default.
• W2034847524 hasAuthorship W2034847524A5017745566 @default.
• W2034847524 hasAuthorship W2034847524A5028989565 @default.
• W2034847524 hasAuthorship W2034847524A5061594020 @default.
• W2034847524 hasAuthorship W2034847524A5076622040 @default.
• W2034847524 hasBestOaLocation W20348475242 @default.
• W2034847524 hasConcept C104317684 @default.
• W2034847524 hasConcept C106208931 @default.
• W2034847524 hasConcept C109007969 @default.
• W2034847524 hasConcept C135763542 @default.
• W2034847524 hasConcept C151730666 @default.
• W2034847524 hasConcept C153209595 @default.
• W2034847524 hasConcept C186413461 @default.
• W2034847524 hasConcept C1893757 @default.
• W2034847524 hasConcept C31467283 @default.
• W2034847524 hasConcept C54355233 @default.
• W2034847524 hasConcept C70721500 @default.
• W2034847524 hasConcept C86803240 @default.
• W2034847524 hasConceptScore W2034847524C104317684 @default.
• W2034847524 hasConceptScore W2034847524C106208931 @default.
• W2034847524 hasConceptScore W2034847524C109007969 @default.
• W2034847524 hasConceptScore W2034847524C135763542 @default.
• W2034847524 hasConceptScore W2034847524C151730666 @default.
• W2034847524 hasConceptScore W2034847524C153209595 @default.
• W2034847524 hasConceptScore W2034847524C186413461 @default.
• W2034847524 hasConceptScore W2034847524C1893757 @default.
• W2034847524 hasConceptScore W2034847524C31467283 @default.
• W2034847524 hasConceptScore W2034847524C54355233 @default.
• W2034847524 hasConceptScore W2034847524C70721500 @default.
• W2034847524 hasConceptScore W2034847524C86803240 @default.
• W2034847524 hasIssue "8" @default.
• W2034847524 hasLocation W20348475241 @default.
• W2034847524 hasLocation W20348475242 @default.
• W2034847524 hasLocation W20348475243 @default.
• W2034847524 hasLocation W20348475244 @default.
• W2034847524 hasOpenAccess W2034847524 @default.
• W2034847524 hasPrimaryLocation W20348475241 @default.
• W2034847524 hasRelatedWork W1486217206 @default.
• W2034847524 hasRelatedWork W1971424770 @default.
• W2034847524 hasRelatedWork W1993755972 @default.
• W2034847524 hasRelatedWork W2066467839 @default.
• W2034847524 hasRelatedWork W2111842731 @default.
• W2034847524 hasRelatedWork W2170506381 @default.
• W2034847524 hasRelatedWork W2594299395 @default.
• W2034847524 hasRelatedWork W2765794416 @default.

• next