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- W2034849945 abstract "The importance of the increasing incidence of multiple-antibiotic-resistant salmonella is noted by Shelley Rankin and Michael Coyne (June 6, p 1740).1Rankin SC Coyne MJ Multiple antibiotic resistance in Salmonella enterica serotype enteritidis.Lancet. 1998; 351: 1740Summary Full Text Full Text PDF PubMed Scopus (14) Google Scholar We would add that antibiotic resistance in Salmonella spp is no longer restricted to older compounds. Salmonella spp resistant to second-generation and third-generation cephalosporins and related antibiotics by the production of various extended-spectrum β-lactamases are increasingly common worldwide.* The reported enzymes include TEM-3 from Salmonella kedougou in France and possibly S enteritidis in Spain, TEM-25 from S mbandanka imported into France from Algeria, and TEM-27 from S othmarschen in Spain. There have been two reports of SHV-2 in S mbandanka, S typhimurium, and S wien, all associated with Tunisia, although the S mbandanka strain was isolated after importation into the UK. We have reported an SHV-5-producing strain of S senftenberg that caused an outbreak of wound infection in a hospital in India.2Revathi G, Shannon KP, Stapleton PD, Jain BK, French GL. An outbreak of extended-spectrum β-lactamase-producing Salmonella senftenburg in a burns ward. J Hosp Infect (in press).Google Scholar Other molecular class A β-lactamases have also been found in salmonella, including CTX-M2 from S typhimurium in Argentina. PER-1 β-lactamase, which was previously seen in only Pseudomonas aeruginosa, was found in two S typhimurium strains in Turkey, one of which caused an outbreak of neonatal meningitis. Two S typhimurium strains that produced PER-type enzymes were reported from Argentina, and one that produced an enzyme that may be related to MEN-1 from Russia. An isolate of S enteritidis from Saudi Arabia produced a plasmid-encoded molecular class C β-lactamase (DHA-1) that conferred resistance to extended-spectrum cephalosporins and cephamycins. Another group I enzyme, CMY-2, was reported in S senftenberg from Algeria. Two unidentified extended-spectrum β-lactamases have also been reported from Algeria and Slovakia. Extended-spectrum β-lactamase production is usually encoded on transmissible plasmids together with a range of aminoglycoside-modifying enzymes,3Jacoby GA Sutton L Properties of plasmids responsible for production of extended-spectrum β-lactamases.Antimicrob Agents Chemother. 1991; 35: 164-169Crossref PubMed Scopus (182) Google Scholar and, therefore, most of these cephalosporin-resistant salmonellas are also resistant to aminoglycosides. The resistance plasmids have probably been acquired from other multidrug-resistant enterobacteriaceae, especially Klebsiella pneumoniae, which are also increasing in incidence worldwide.4Livermore DM β-lactamase-mediated resistance and opportunities for its control.J Antimicrob Chemother. 1998; 41: 25-41Crossref PubMed Scopus (190) Google Scholar We agree with Rankin and Coyn that an effective strategy for the containment of antibiotic resistance in foodborne pathogens is needed, but would add that enteric pathogens can also acquire multiple resistances by conjugation with commensal bacteria in the human bowel. Although most cases of human illness from Salmonella spp do not need to be treated with cephalosporins or aminoglycosides, these antibiotics are useful in invasive complications such as bacteraemias and meningitis." @default.
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- W2034849945 title "Multiple-antibiotic-resistant salmonella" @default.
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- W2034849945 doi "https://doi.org/10.1016/s0140-6736(05)79231-x" @default.
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