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- W2034850152 abstract "The effect of prostaglandin E<sub>2</sub> (PGE<sub>2</sub>) injection on the postnatal maturation of the 16-day-old rodent small intestine was studied. Previous studies have shown that 16,16-dimethyl PGE<sub>2</sub> induced several morphological and biochemical parameters in the small intestine of 11-day-old rats. PGE<sub>2</sub> was given subcutaneously daily at doses of 2 and 4 mg/kg body weight on postnatal days 11–15. After treatment there was a rise in the mean activities of sucrase, maltase, lactase and aminopeptidase. In rats receiving 4 mg/kg PGE<sub>2</sub>, sucrase activity was strongly stimulated (p < 0.001) in the proximal and the distal small bowel. In the duodenum, PGE<sub>2</sub> treatment (4 mg/kg body weight) produced a significant increase in crypt depth (35%, p < 0.001), although villus height was not modified. Serum corticosterone levels were significantly increased in PGE<sub>2</sub>-treated rats. The results seem to indicate that PGE<sub>2</sub> accelerates enzymatic and morphological intestinal maturation and this effect could be mediated by an increase in corticosterone." @default.
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- W2034850152 title "Prostaglandin E<sub>2</sub> Accelerates Enzymatic and Morphological Maturation of the Small Intestine in Suckling Rats" @default.
- W2034850152 doi "https://doi.org/10.1159/000244037" @default.
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