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- W2034850161 abstract "The biosynthetic gene cluster governing production of anti-infective marformycins was identified from deep sea-derived Streptomyces drozdowiczii SCSIO 10141. The putative mfn gene cluster (45 kb, 20 orfs) was found to encode six NRPSs and related proteins for cyclodepsipeptide core construction (mfnCDEFKL), a methionyl-tRNA formyltransferase (mfnA), a SAM-dependent methyltransferase (mfnG), and a cytochrome P450 monooxygenase for piperazic acid moiety hydroxylation (mfnN); notably, only MfnN uses an intact cyclodepsipeptide intermediate as its substrate." @default.
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- W2034850161 date "2015-03-06" @default.
- W2034850161 modified "2023-10-14" @default.
- W2034850161 title "Biosynthesis of the Anti-infective Marformycins Featuring Pre-NRPS Assembly Line <i>N</i>-Formylation and <i>O</i>-Methylation and Post-Assembly Line <i>C</i>-Hydroxylation Chemistries" @default.
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- W2034850161 doi "https://doi.org/10.1021/acs.orglett.5b00389" @default.
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