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• W2034850521 abstract "Interferon-γ (IFN-γ) exhibits various properties including antigrowth activity in neoplastic and normal cells and regulatory roles in immune responses and hematopoiesis, but studies of IFN-γ effects on human megakaryopoiesis have been inconclusive. Recently we have used serum-free culture of purified CD34+ cells to demonstrate that IFN-γ stimulates the proliferation of relatively mature megakaryocytic progenitors independently of thrombopoietin. It has been also shown that IFN-γ stimulates the maturation of megakaryocytes, and has a significant synergism with stem cell factor in human megakaryopoiesis. Further studies are needed to clarify the in vivo effect of IFN-γ on human megakaryopoiesis and the clinical relevance of IFN-γ." @default.
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• W2034850521 date "1998-01-01" @default.
• W2034850521 modified "2023-10-16" @default.
• W2034850521 title "Interferon-γ and Human Megakaryopoiesis" @default.
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• W2034850521 doi "https://doi.org/10.3109/10428199809057590" @default.
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