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- W2034851556 abstract "Abstract The ethionamide sensitivity of cultures of M. tuberculosis isolated from East African patients has been measured in population-study sensitivity tests. The results have been expressed as MICs using large or small inocula, and by the proportion method. Pre-treatment cultures which were naturally sensitive or naturally resistant to thiacetazone did not differ appreciably in their sensitivity to ethionamide. Pairs of cultures obtained before and after six months treatment with isoniazid plus thiacetazone were found to differ significantly in their sensitivity to ethionamide. Although none of the pre-treatment cultures were resistant to ethionamide, six of 21 post-treatment cultures were definitely resistant. It is concluded that natural resistance to thiacetazone is not accompanied by resistance to ethionamide; whereas among cultures with acquired resistance to thiacetazone approximately 30 % are also resistant to ethionamide." @default.
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- W2034851556 date "1969-03-01" @default.
- W2034851556 modified "2023-09-27" @default.
- W2034851556 title "The ethionamide sensitivity of east african strains of mycobacterium tuberculosis resistant to thiacetazone" @default.
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- W2034851556 doi "https://doi.org/10.1016/0041-3879(69)90003-8" @default.
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