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- W2034851913 abstract "Although the v-abl gene can provoke several types of lymphoid neoplasm, mice of a transgenic strain (Em̈-v-abl 40) in which lymphocytes are targeted for expression of v-abl by a linked immunoglobulin enhancer (Em̈) spontaneously develop only plasmacytomas. To determine whether other lymphocytes of this strain were susceptible to transformation, and to identify genes that can collaborate with v-abl in tumorigenesis, Em̈-v-abl 40 mice were subjected to insertional mutagenesis by neonatal infection with Moloney murine leukemia virus. Tumorigenesis was accelerated moderately, but nearly all the tumors were T lymphomas. The altered tumor type may reflect both the T-cell tropism of Moloney virus and the higher level of Em̈-v-abl 40 expression found in T lymphocytes than in B lymphocytes. Insertion near the c-myc, N-myc or pim-1 gene was observed in 42% of the induced tumors, indicating that each of these genes may collaborate with v-abl in lymphomagenesis. Most of the accelerated tumors had a surprisingly low level of transgene expression. Thus, high expression of v-abl may not be required for Moloney-induced T lymphomagenesis." @default.
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- W2034851913 date "1993-10-21" @default.
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- W2034851913 title "Moloney virus induction of T-cell lymphomas in a plasmacytomagenic strain of Eμ-V-ABL transgenic mice" @default.
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- W2034851913 doi "https://doi.org/10.1002/ijc.2910550418" @default.
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