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- W2034852624 abstract "Tetrapeptides derived from glycine and β-alanine were hooked at the C-3β position of the modified cholic acid to realize novel linear tetrapeptide-linked cholic acid derivatives. All the synthesized compounds were tested against a wide variety of microorganisms (Gram-negative bacteria, Gram-positive bacteria and fungi) and their cytotoxicity was evaluated against human embryonic kidney (HEK293) and human mammary adenocarcinoma (MCF-7) cell lines. While relatively inactive by themselves, these compounds interact synergistically with antibiotics such as fluconazole and erythromycin to inhibit growth of fungi and bacteria, respectively, at 1–24 μg/mL. The synergistic effect shown by our novel compounds is due to their inherent amphiphilicity. The fractional inhibitory concentrations reported are comparable to those reported for Polymyxin B derivatives." @default.
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- W2034852624 date "2008-10-01" @default.
- W2034852624 modified "2023-10-09" @default.
- W2034852624 title "Synthesis of chimeric tetrapeptide-linked cholic acid derivatives: Impending synergistic agents" @default.
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- W2034852624 doi "https://doi.org/10.1016/j.bmcl.2008.09.013" @default.
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