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- W2034853669 abstract "1. 1. The adrenergic agonists, noradrenalin (mainly an α-agonist) and isoprenalin (isoproterenol, mainly a β-agonist) produced a marked increase of 32 P-incorporation into phosphatidylinositol of rat vas deferens slices. Other tissue phospholipids did not show the same effect. 2. 2. 32 P-incorporation into phospholipids of the vas deferens increased with time and in the presence of noradrenalin or isoprenalin. The extent of labelling of phosphatidylinositol was related to the concentration of these adrenergic agonists. 3. 3. Adrenergic blocking agents were used to prevent the action of noradrenalin or isoprenalin on 32 P-incorporation into phosphatidylinositol. Phenoxybenzamine (α-blocker) and sotalol (β-blocker) did not appreciably change the basal 32 P-incorporation into phosphatidylinositol. Phentolamine (α-blocker) was found to stimulate the phosphatidylinositol labelling. 4. 4. Preincubation with phenoxybenzamine resulted in a marked decrease of the noradrenalin and isoprenalin stimulation of phosphatidylinositol labelling but preincubation with sotalol had no effect. 5. 5. It appears that the adrenergic stimulation of phosphatidylinositol metabolism in vas deferens is mediated through α-adrenergic receptors." @default.
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- W2034853669 date "1974-09-01" @default.
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- W2034853669 title "Adrenergic stimulation of phosphatidylinositol labelling in rat vas deferens" @default.
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- W2034853669 doi "https://doi.org/10.1016/0005-2760(74)90059-9" @default.
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