FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034853748> ?p ?o ?g. }

• W2034853748 endingPage "345" @default.
• W2034853748 startingPage "337" @default.
• W2034853748 abstract "Recently, we have demonstrated that sensory neurons of rat lumbar dorsal root ganglia (DRG) respond to hypoxia with an activation of endothelial nitric oxide (NO) synthase (eNOS) resulting in enhanced NO production associated with mitochondria which contributes to resistance against hypoxia. Extracellular calcium is essential to this effect. In the present study on rat DRG slices, we set out to determine what types of calcium channels operate under hypoxia, and which upstream events contribute to their activation, thereby focusing upon mitochondrial complex II. Both the metallic ions Cd2+ and Ni2+, known to inhibit voltage-gated calcium channels and T-type channels, respectively, and verapamil and nifedipine, typical blocker of L-type calcium channels completely prevented the hypoxic neuronal NO generation. Inhibition of complex II by thenoyltrifluoroacetone at the ubiquinon binding site or by 3-nitropropionic acid at the substrate binding site largely diminished hypoxic-induced NO production while having an opposite effect under normoxia. An additional blockade of voltage-gated calcium channels entirely abolished the hypoxic response. The complex II inhibitor malonate inhibited both normoxic and hypoxic NO generation. These data show that complex II activity is required for increased hypoxic NO production. Since succinate dehydrogenase activity of complex II decreased at hypoxia, as measured by histochemistry and densitometry, we propose a hypoxia-induced functional switch of complex II from succinate dehydrogenase to fumarate reductase, which subsequently leads to activation of voltage-gated calcium channels resulting in increased NO production by eNOS." @default.
• W2034853748 created "2016-06-24" @default.
• W2034853748 creator A5022405232 @default.
• W2034853748 creator A5034541589 @default.
• W2034853748 creator A5036218939 @default.
• W2034853748 creator A5037658208 @default.
• W2034853748 creator A5038514497 @default.
• W2034853748 creator A5048320574 @default.
• W2034853748 creator A5088758015 @default.
• W2034853748 date "2004-01-01" @default.
• W2034853748 modified "2023-09-25" @default.
• W2034853748 title "Hypoxic increase in nitric oxidegeneration of rat sensory neurons requires activation of mitochondrial complex II and voltage-gated calcium channels" @default.
• W2034853748 cites W1497205192 @default.
• W2034853748 cites W1547863599 @default.
• W2034853748 cites W1565300999 @default.
• W2034853748 cites W1583450756 @default.
• W2034853748 cites W1964711009 @default.
• W2034853748 cites W1965348370 @default.
• W2034853748 cites W1965597993 @default.
• W2034853748 cites W1983423336 @default.
• W2034853748 cites W1992377678 @default.
• W2034853748 cites W2002935961 @default.
• W2034853748 cites W2007425036 @default.
• W2034853748 cites W2015033155 @default.
• W2034853748 cites W2026525843 @default.
• W2034853748 cites W2029155832 @default.
• W2034853748 cites W2032282434 @default.
• W2034853748 cites W2040809342 @default.
• W2034853748 cites W2066566361 @default.
• W2034853748 cites W2073398798 @default.
• W2034853748 cites W2078259930 @default.
• W2034853748 cites W2099185169 @default.
• W2034853748 cites W2124451529 @default.
• W2034853748 cites W2163000500 @default.
• W2034853748 cites W2172190038 @default.
• W2034853748 cites W2249636885 @default.
• W2034853748 cites W268742540 @default.
• W2034853748 cites W50072272 @default.
• W2034853748 cites W7827006 @default.
• W2034853748 doi "https://doi.org/10.1016/j.neuroscience.2004.06.057" @default.
• W2034853748 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15350645" @default.
• W2034853748 hasPublicationYear "2004" @default.
• W2034853748 type Work @default.
• W2034853748 sameAs 2034853748 @default.
• W2034853748 citedByCount "12" @default.
• W2034853748 countsByYear W20348537482012 @default.
• W2034853748 countsByYear W20348537482014 @default.
• W2034853748 countsByYear W20348537482015 @default.
• W2034853748 countsByYear W20348537482020 @default.
• W2034853748 crossrefType "journal-article" @default.
• W2034853748 hasAuthorship W2034853748A5022405232 @default.
• W2034853748 hasAuthorship W2034853748A5034541589 @default.
• W2034853748 hasAuthorship W2034853748A5036218939 @default.
• W2034853748 hasAuthorship W2034853748A5037658208 @default.
• W2034853748 hasAuthorship W2034853748A5038514497 @default.
• W2034853748 hasAuthorship W2034853748A5048320574 @default.
• W2034853748 hasAuthorship W2034853748A5088758015 @default.
• W2034853748 hasConcept C12554922 @default.
• W2034853748 hasConcept C126322002 @default.
• W2034853748 hasConcept C134018914 @default.
• W2034853748 hasConcept C174293024 @default.
• W2034853748 hasConcept C178790620 @default.
• W2034853748 hasConcept C185592680 @default.
• W2034853748 hasConcept C18699975 @default.
• W2034853748 hasConcept C2777622882 @default.
• W2034853748 hasConcept C30979828 @default.
• W2034853748 hasConcept C519063684 @default.
• W2034853748 hasConcept C519581460 @default.
• W2034853748 hasConcept C55493867 @default.
• W2034853748 hasConcept C71924100 @default.
• W2034853748 hasConcept C86803240 @default.
• W2034853748 hasConcept C95444343 @default.
• W2034853748 hasConceptScore W2034853748C12554922 @default.
• W2034853748 hasConceptScore W2034853748C126322002 @default.
• W2034853748 hasConceptScore W2034853748C134018914 @default.
• W2034853748 hasConceptScore W2034853748C174293024 @default.
• W2034853748 hasConceptScore W2034853748C178790620 @default.
• W2034853748 hasConceptScore W2034853748C185592680 @default.
• W2034853748 hasConceptScore W2034853748C18699975 @default.
• W2034853748 hasConceptScore W2034853748C2777622882 @default.
• W2034853748 hasConceptScore W2034853748C30979828 @default.
• W2034853748 hasConceptScore W2034853748C519063684 @default.
• W2034853748 hasConceptScore W2034853748C519581460 @default.
• W2034853748 hasConceptScore W2034853748C55493867 @default.
• W2034853748 hasConceptScore W2034853748C71924100 @default.
• W2034853748 hasConceptScore W2034853748C86803240 @default.
• W2034853748 hasConceptScore W2034853748C95444343 @default.
• W2034853748 hasIssue "2" @default.
• W2034853748 hasLocation W20348537481 @default.
• W2034853748 hasLocation W20348537482 @default.
• W2034853748 hasOpenAccess W2034853748 @default.
• W2034853748 hasPrimaryLocation W20348537481 @default.
• W2034853748 hasRelatedWork W1601947680 @default.
• W2034853748 hasRelatedWork W17069625 @default.
• W2034853748 hasRelatedWork W1982194850 @default.
• W2034853748 hasRelatedWork W2045160111 @default.
• W2034853748 hasRelatedWork W2046962705 @default.
• W2034853748 hasRelatedWork W2058619297 @default.

• next