Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034853882> ?p ?o ?g. }
Showing items 1 to 95 of
95
with 100 items per page.
- W2034853882 endingPage "33" @default.
- W2034853882 startingPage "30" @default.
- W2034853882 abstract "Background: Limited resources and the expense of Activated Protein C (APC) (drotrecogin alfa) may contribute to the reluctance to utilize this drug in sepsis. Employing the PROWESS criteria resulted in absolute reduction in 28-day mortality of 6.1%, representing a relative risk reduction of 19.4%. Additional patient categorization and selection may lead to less frequent drug use with the same survival advantage. We used transcutaneous partial pressure of oxygen (PtcO2) as an indicator of microcirculatory perfusion to identify which septic patients may benefit from APC. Methods: Nineteen patients consecutively admitted with severe sepsis or septic shock that fulfilled the PROWESS criteria for APC treatment. APC was administered to patients with the PROWESS selection criteria, only if the PtcO2 information demonstrated tissue ischemia. Results: Nineteen patients met the PROWESS criteria. Ten patients demonstrated poor tissue perfusion using PtcO2 monitors and received APC. Nine patients had adequate tissue perfusion and did not receive APC. There were no differences in age, gender, APACHE II scores, lactate levels, or organ failure between the two groups. The 10 patients who received APC had a mortality of 3 of 10 (30%). The survivors of this group uniformly converted to PtcO2 values consistent with survival within 12 hours to 24 hours of drug administration. The nine patients who did not receive APC had a mortality of 2 of 9 (22%), not statistically significant from those who received the drug (p = 0.89). Conclusion: Withholding APC did not result in an increase in mortality from severe sepsis in those patients who demonstrated adequate PtcO2 values. The transcutaneous oxygen measurement may be a useful adjuvant in addition to the other selection criteria for better identification of patients who may benefit from APC." @default.
- W2034853882 created "2016-06-24" @default.
- W2034853882 creator A5003144748 @default.
- W2034853882 creator A5011557756 @default.
- W2034853882 creator A5012677167 @default.
- W2034853882 creator A5021424666 @default.
- W2034853882 creator A5027541283 @default.
- W2034853882 creator A5065090324 @default.
- W2034853882 date "2008-07-01" @default.
- W2034853882 modified "2023-09-30" @default.
- W2034853882 title "Using Transcutaneous Oxygen Pressure Measurements as Selection Criteria for Activated Protein C Use" @default.
- W2034853882 cites W1846347013 @default.
- W2034853882 cites W1964077707 @default.
- W2034853882 cites W1964313021 @default.
- W2034853882 cites W1998454156 @default.
- W2034853882 cites W2025503048 @default.
- W2034853882 cites W2029167131 @default.
- W2034853882 cites W2032596408 @default.
- W2034853882 cites W2033626564 @default.
- W2034853882 cites W2035233871 @default.
- W2034853882 cites W2042532113 @default.
- W2034853882 cites W2050280222 @default.
- W2034853882 cites W2052497202 @default.
- W2034853882 cites W2062840385 @default.
- W2034853882 cites W2064579097 @default.
- W2034853882 cites W2073536973 @default.
- W2034853882 cites W2074531973 @default.
- W2034853882 cites W2083835986 @default.
- W2034853882 cites W2084031214 @default.
- W2034853882 cites W2084443600 @default.
- W2034853882 cites W2084640166 @default.
- W2034853882 cites W2105878994 @default.
- W2034853882 cites W2119845428 @default.
- W2034853882 cites W2132378640 @default.
- W2034853882 cites W2135077274 @default.
- W2034853882 cites W2137623047 @default.
- W2034853882 cites W2157262751 @default.
- W2034853882 cites W2181563581 @default.
- W2034853882 cites W2322079999 @default.
- W2034853882 cites W2322121630 @default.
- W2034853882 cites W2404106741 @default.
- W2034853882 doi "https://doi.org/10.1097/ta.0b013e3180eeab28" @default.
- W2034853882 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18580526" @default.
- W2034853882 hasPublicationYear "2008" @default.
- W2034853882 type Work @default.
- W2034853882 sameAs 2034853882 @default.
- W2034853882 citedByCount "3" @default.
- W2034853882 countsByYear W20348538822017 @default.
- W2034853882 crossrefType "journal-article" @default.
- W2034853882 hasAuthorship W2034853882A5003144748 @default.
- W2034853882 hasAuthorship W2034853882A5011557756 @default.
- W2034853882 hasAuthorship W2034853882A5012677167 @default.
- W2034853882 hasAuthorship W2034853882A5021424666 @default.
- W2034853882 hasAuthorship W2034853882A5027541283 @default.
- W2034853882 hasAuthorship W2034853882A5065090324 @default.
- W2034853882 hasConcept C126322002 @default.
- W2034853882 hasConcept C141071460 @default.
- W2034853882 hasConcept C146957229 @default.
- W2034853882 hasConcept C177713679 @default.
- W2034853882 hasConcept C2777628635 @default.
- W2034853882 hasConcept C2778384902 @default.
- W2034853882 hasConcept C2781287897 @default.
- W2034853882 hasConcept C2994086866 @default.
- W2034853882 hasConcept C71924100 @default.
- W2034853882 hasConceptScore W2034853882C126322002 @default.
- W2034853882 hasConceptScore W2034853882C141071460 @default.
- W2034853882 hasConceptScore W2034853882C146957229 @default.
- W2034853882 hasConceptScore W2034853882C177713679 @default.
- W2034853882 hasConceptScore W2034853882C2777628635 @default.
- W2034853882 hasConceptScore W2034853882C2778384902 @default.
- W2034853882 hasConceptScore W2034853882C2781287897 @default.
- W2034853882 hasConceptScore W2034853882C2994086866 @default.
- W2034853882 hasConceptScore W2034853882C71924100 @default.
- W2034853882 hasIssue "1" @default.
- W2034853882 hasLocation W20348538821 @default.
- W2034853882 hasLocation W20348538822 @default.
- W2034853882 hasOpenAccess W2034853882 @default.
- W2034853882 hasPrimaryLocation W20348538821 @default.
- W2034853882 hasRelatedWork W1025743729 @default.
- W2034853882 hasRelatedWork W2016213571 @default.
- W2034853882 hasRelatedWork W2036932947 @default.
- W2034853882 hasRelatedWork W2039562566 @default.
- W2034853882 hasRelatedWork W2045983404 @default.
- W2034853882 hasRelatedWork W2184362486 @default.
- W2034853882 hasRelatedWork W2407316552 @default.
- W2034853882 hasRelatedWork W2417203482 @default.
- W2034853882 hasRelatedWork W4322389475 @default.
- W2034853882 hasRelatedWork W2117165409 @default.
- W2034853882 hasVolume "65" @default.
- W2034853882 isParatext "false" @default.
- W2034853882 isRetracted "false" @default.
- W2034853882 magId "2034853882" @default.
- W2034853882 workType "article" @default.